Bidirectional genetic overlap between bipolar disorder and intelligence

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	Bidirectional genetic overlap between bipolar disorder and intelligence
	Shang, MY; Wu, Y; Zhang, CY; Qi, HX; Zhang, Q; Huo, JH; Wang, L; Wang, C; Li, M
	2022
发表期刊	BMC MEDICINE
ISSN	1741-7015
卷号	20 期号:1
摘要	Background Bipolar disorder (BD) is a highly heritable psychiatric illness exhibiting substantial correlation with intelligence. Methods To investigate the shared genetic signatures between BD and intelligence, we utilized the summary statistics from genome-wide association studies (GWAS) to conduct the bivariate causal mixture model (MiXeR) and conjunctional false discovery rate (conjFDR) analyses. Subsequent expression quantitative trait loci (eQTL) mapping in human brain and enrichment analyses were also performed. Results Analysis with MiXeR suggested that approximately 10.3K variants could influence intelligence, among which 7.6K variants were correlated with the risk of BD (Dice: 0.80), and 47% of these variants predicted BD risk and intelligence in consistent allelic directions. The conjFDR analysis identified 37 distinct genomic loci that were jointly associated with BD and intelligence with a conjFDR < 0.01, and 16 loci (43%) had the same directions of allelic effects in both phenotypes. Brain eQTL analyses found that genes affected by the concordant loci were distinct from those modulated by the discordant loci. Enrichment analyses suggested that genes related to the concordant loci were significantly enriched in pathways/phenotypes related with synapses and sleep quality, whereas genes associated with the discordant loci were enriched in pathways related to cell adhesion, calcium ion binding, and abnormal emotional phenotypes. Conclusions We confirmed the polygenic overlap with mixed directions of allelic effects between BD and intelligence and identified multiple genomic loci and risk genes. This study provides hints for the mesoscopic phenotypes of BD and relevant biological mechanisms, promoting the knowledge of the genetic and phenotypic heterogeneity of BD. The essential value of leveraging intelligence in BD investigations is also highlighted.
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/13736
专题	科研部门_转化基因组（李明）
推荐引用方式 GB/T 7714	Shang, MY,Wu, Y,Zhang, CY,et al. Bidirectional genetic overlap between bipolar disorder and intelligence[J]. BMC MEDICINE,2022,20(1).
APA	Shang, MY.,Wu, Y.,Zhang, CY.,Qi, HX.,Zhang, Q.,...&Li, M.(2022).Bidirectional genetic overlap between bipolar disorder and intelligence.BMC MEDICINE,20(1).
MLA	Shang, MY,et al."Bidirectional genetic overlap between bipolar disorder and intelligence".BMC MEDICINE 20.1(2022).

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