Integrative omics of schizophrenia: from genetic determinants to clinical classification and risk prediction

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	Integrative omics of schizophrenia: from genetic determinants to clinical classification and risk prediction
	Guan, FL; Ni, T; Zhu, WL; Williams, LK; Cui, LB; Li, M; Tubbs, J; Sham, PC; Gui, HS
	2022
发表期刊	MOLECULAR PSYCHIATRY
ISSN	1359-4184
卷号	27 期号:1 页码:113-126
摘要	Schizophrenia (SCZ) is a debilitating neuropsychiatric disorder with high heritability and complex inheritance. In the past decade, successful identification of numerous susceptibility loci has provided useful insights into the molecular etiology of SCZ. However, applications of these findings to clinical classification and diagnosis, risk prediction, or intervention for SCZ have been limited, and elucidating the underlying genomic and molecular mechanisms of SCZ is still challenging. More recently, multiple Omics technologies - genomics, transcriptomics, epigenomics, proteomics, metabolomics, connectomics, and gut microbiomics - have all been applied to examine different aspects of SCZ pathogenesis. Integration of multi-Omics data has thus emerged as an approach to provide a more comprehensive view of biological complexity, which is vital to enable translation into assessments and interventions of clinical benefit to individuals with SCZ. In this review, we provide a broad survey of the single-omics studies of SCZ, summarize the advantages and challenges of different Omics technologies, and then focus on studies in which multiple omics data are integrated to unravel the complex pathophysiology of SCZ. We believe that integration of multi-Omics technologies would provide a roadmap to create a more comprehensive picture of interactions involved in the complex pathogenesis of SCZ, constitute a rich resource for elucidating the potential molecular mechanisms of the illness, and eventually improve clinical assessments and interventions of SCZ to address clinical translational questions from bench to bedside.
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/13744
专题	科研部门_转化基因组（李明）
推荐引用方式 GB/T 7714	Guan, FL,Ni, T,Zhu, WL,et al. Integrative omics of schizophrenia: from genetic determinants to clinical classification and risk prediction[J]. MOLECULAR PSYCHIATRY,2022,27(1):113-126.
APA	Guan, FL.,Ni, T.,Zhu, WL.,Williams, LK.,Cui, LB.,...&Gui, HS.(2022).Integrative omics of schizophrenia: from genetic determinants to clinical classification and risk prediction.MOLECULAR PSYCHIATRY,27(1),113-126.
MLA	Guan, FL,et al."Integrative omics of schizophrenia: from genetic determinants to clinical classification and risk prediction".MOLECULAR PSYCHIATRY 27.1(2022):113-126.

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2023040730.pdf（1112KB）	期刊论文	出版稿	开放获取	CC BY-NC-SA	请求全文