| Novel Meroterpenoids from Hypericum patulum: Highly Potent Late Na(v)1.5 Sodium Current Inhibitors |
| Ye, YS; Du, SZ; Jiang, NN; Xu, HX; Yang, J; Fu, WW; Nian, Y; Xu, G
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| 2020
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| 发表期刊 | ORGANIC LETTERS
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| ISSN | 1523-7060
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| 卷号 | 22期号:16页码:6339-6343 |
| 摘要 | Hypulatones A and B (1 and 2), two racemic meroterpenoids possessing an unprecedented spiro[benzofuran-2,1'-cycloundecan]-4'-ene-4,6(5H)-dione core, were characterized from Hypericum patulum. Compound 2 was found to significantly inhibit the late current of Na(v)1.5 (late I-Na, IC50 = 0.2 mu M). Importantly, 2 exhibited remarkable separation (>100-fold) of late I-Na relative to peak I-Na and notable selectivity over Ca(v)3.1, K(v)1.5, and hERG. 1 showed comparable inhibition on late I-Na compared to that of 2 with poorer selectivity. |
| 收录类别 | sci
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| 语种 | 英语
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| 文献类型 | 期刊论文
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| 条目标识符 | http://ir.kiz.ac.cn/handle/152453/13787
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| 专题 | 科研部门_天然药物功能蛋白质学科组（赖仞）
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推荐引用方式
GB/T 7714 |
Ye, YS,Du, SZ,Jiang, NN,et al. Novel Meroterpenoids from Hypericum patulum: Highly Potent Late Na(v)1.5 Sodium Current Inhibitors[J]. ORGANIC LETTERS,2020,22(16):6339-6343.
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| APA |
Ye, YS.,Du, SZ.,Jiang, NN.,Xu, HX.,Yang, J.,...&Xu, G.(2020).Novel Meroterpenoids from Hypericum patulum: Highly Potent Late Na(v)1.5 Sodium Current Inhibitors.ORGANIC LETTERS,22(16),6339-6343.
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| MLA |
Ye, YS,et al."Novel Meroterpenoids from Hypericum patulum: Highly Potent Late Na(v)1.5 Sodium Current Inhibitors".ORGANIC LETTERS 22.16(2020):6339-6343.
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