| Scholarinine A, a N-3 type caged-monoterpene indole alkaloid as Ca(v)3.1 T-type calcium channel inhibitor from Alstonia scholaris |
| Zhan, R; Du, SZ; Duan, ZH; Nian, Y; Chen, YG
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| 2020
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| 发表期刊 | TETRAHEDRON LETTERS
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| ISSN | 0040-4039
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| 卷号 | 61期号:1 |
| 摘要 | Scholarinine A (1), a new N-3-type caged monoterpene indole alkaloid was isolated from the branches and leaves of Alstonia scholaris. Structurally, 1 is featured by unique 6/5/6/5/5/6 carbocyclic skeleton bearing a novel imidazolidine ring E. The structure of I was determined by extensive spectroscopic analyses and X-ray crystallography. Biological studies exhibited that compound 1 is a potent Ca(v)3.1 T-type calcium channel inhibitor with an IC50 value of 4.28 mu M. In addition, 1 enhanced the neurite outgrowth of nerve growth factor (NGF) mediated PC12 cells at 10 mu M. (C) 2019 Elsevier Ltd. All rights reserved. |
| 收录类别 | sci
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| 语种 | 英语
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| 文献类型 | 期刊论文
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| 条目标识符 | http://ir.kiz.ac.cn/handle/152453/13789
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| 专题 | 科研部门_天然药物功能蛋白质学科组（赖仞）
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推荐引用方式
GB/T 7714 |
Zhan, R,Du, SZ,Duan, ZH,et al. Scholarinine A, a N-3 type caged-monoterpene indole alkaloid as Ca(v)3.1 T-type calcium channel inhibitor from Alstonia scholaris[J]. TETRAHEDRON LETTERS,2020,61(1).
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| APA |
Zhan, R,Du, SZ,Duan, ZH,Nian, Y,&Chen, YG.(2020).Scholarinine A, a N-3 type caged-monoterpene indole alkaloid as Ca(v)3.1 T-type calcium channel inhibitor from Alstonia scholaris.TETRAHEDRON LETTERS,61(1).
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| MLA |
Zhan, R,et al."Scholarinine A, a N-3 type caged-monoterpene indole alkaloid as Ca(v)3.1 T-type calcium channel inhibitor from Alstonia scholaris".TETRAHEDRON LETTERS 61.1(2020).
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