Inherited OKT4 epitope deficiency in a Chinese rhesus macaque

	Inherited OKT4 epitope deficiency in a Chinese rhesus macaque
	Liu, BB; Zhao, ML; Wang, Y; Hu, ZF; Zheng, YT; Tian, RR
	2021
发表期刊	JOURNAL OF MEDICAL PRIMATOLOGY
ISSN	0047-2565
卷号	50 期号:3 页码:185-188
摘要	OKT4 is an important epitope of the CD4 molecular. Amino acid mutations in the CD4V3 region result in deficiency of the OKT4 epitope in human. Here, we firstly reported a case of hereditary deficiency of OKT4 epitope in an inbred Chinese rhesus macaque family. This epitope deficiency is due to cytosine to thymine transition and homozygote at the nucleotide position 793 of CD4 coding sequences, which leads to the replace of arginine at 265th position of CD4 molecule by tryptophan. The results reveal that OKT4 epitope deficiency is a very old phenotype and may be parentally inherited, and emphasize the importance of avoiding inbreeding in primate population breeding.
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/13803
专题	科研部门_分子免疫药理学（郑永唐）
推荐引用方式 GB/T 7714	Liu, BB,Zhao, ML,Wang, Y,et al. Inherited OKT4 epitope deficiency in a Chinese rhesus macaque[J]. JOURNAL OF MEDICAL PRIMATOLOGY,2021,50(3):185-188.
APA	Liu, BB,Zhao, ML,Wang, Y,Hu, ZF,Zheng, YT,&Tian, RR.(2021).Inherited OKT4 epitope deficiency in a Chinese rhesus macaque.JOURNAL OF MEDICAL PRIMATOLOGY,50(3),185-188.
MLA	Liu, BB,et al."Inherited OKT4 epitope deficiency in a Chinese rhesus macaque".JOURNAL OF MEDICAL PRIMATOLOGY 50.3(2021):185-188.

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