Human immunodeficiency virus: The potential of medicinal plants as antiretroviral therapy

	Human immunodeficiency virus: The potential of medicinal plants as antiretroviral therapy
	Shahzad, M; Chen, H; Akhtar, T; Rafi, A; Zafar, MS; Zheng, YT
	2022
发表期刊	JOURNAL OF MEDICAL VIROLOGY
ISSN	0146-6615
卷号	94 期号:6 页码:2669-2674
摘要	Human immunodeficiency virus (HIV) infection is fast becoming widespread in the world with 37.7 million people living with HIV in 2020. Antiretroviral therapy involving chemical drugs has declined acquired immunodeficiency syndrome (AIDS)-related mortality and improved the life quality of AIDS/HIV sufferers. However, the emergence of drug resistance and side effects are the main obstacles for the long-term use of these chemicals as antiretroviral therapy. Recently, a lot of emphasis is being put on finding naturally occurring drug candidates that show activity against HIV and can be potentially used as antiretroviral therapy. In this study, different medicinal plants, Pistacia khinjuk, Teucrium stocksianum, Uncaria tomentosa, Pistacia integerrima, Trigonella gharuensis, and Artocarpus lakoocha, were explored for their anti-HIV potential. Syncytium and p24 assays were performed to determine antiviral activity, while the MTT assay was used to determine cytotoxicity. Results showed that extracts from all six plants inhibited HIV replication in vitro. Also, extracts from Pistacia khinjuk, Teucrium stocksianum, Uncaria tomentosa, and Pistacia integerrima showed low cytotoxicity with a 50% cytotoxicity concentration value of >200 mu M. Results of this study indicate that there is potential in these natural extracts to become candidate drugs to be used as complementary and alternative medicine for HIV infection.
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/13808
专题	科研部门_分子免疫药理学（郑永唐）
推荐引用方式 GB/T 7714	Shahzad, M,Chen, H,Akhtar, T,et al. Human immunodeficiency virus: The potential of medicinal plants as antiretroviral therapy[J]. JOURNAL OF MEDICAL VIROLOGY,2022,94(6):2669-2674.
APA	Shahzad, M,Chen, H,Akhtar, T,Rafi, A,Zafar, MS,&Zheng, YT.(2022).Human immunodeficiency virus: The potential of medicinal plants as antiretroviral therapy.JOURNAL OF MEDICAL VIROLOGY,94(6),2669-2674.
MLA	Shahzad, M,et al."Human immunodeficiency virus: The potential of medicinal plants as antiretroviral therapy".JOURNAL OF MEDICAL VIROLOGY 94.6(2022):2669-2674.

条目包含的文件
文件名称/大小	文献类型	版本类型	开放类型	使用许可
2023041118.pdf（836KB）	期刊论文	出版稿	开放获取	CC BY-NC-SA	请求全文