| Transcription Factor ZNF683 Inhibits SIV/HIV Replication through Regulating IFN gamma Secretion of CD8+T Cells |
| Lu, Y; Zhang, MX; Pang, W; Song, TZ; Zheng, HY; Tian, RR; Zheng, YT
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| 2022
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| 发表期刊 | VIRUSES-BASEL
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| 卷号 | 14期号:4页码:-0 |
| 摘要 | Pulmonary microbial invasion frequently occurs during AIDS progression in HIV patients. Inflammatory cytokines and other immunoregulatory factors play important roles in this process. We previously established an AIDS model of SIVmac239 infection in northern pig-tailed macaques (NPMs), which were divided into rapid progressor (RP) and slow progressor (SP) groups according to their AIDS progression rates. In this study, we performed 16S rDNA and transcriptome sequencing of the lungs to reveal the molecular mechanism underlying the difference in progression rate between the RPs and SPs. We found that microbial invasion in the RP group was distinct from that in the SP group, showing marker flora of the Family XI, Enterococcus and Ezakiella, and more Lactobacilli. Through pulmonary transcriptome analysis, we found that the transcription factor ZNF683 had higher expression in the SP group than in the RP group. In subsequent functional experiments, we found that ZNF683 increased the proliferation and IFNy secretion ability of CD8+ T cells, thus decreasing SW or HIV replication, which may be related to AIDS progression in SIVmac239-infected NPMs. This study helps elucidate the various complexities of disease progression in HIV-1-infected individuals. |
| 收录类别 | sci
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| 语种 | 英语
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| 文献类型 | 期刊论文
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| 条目标识符 | http://ir.kiz.ac.cn/handle/152453/13810
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| 专题 | 科研部门_分子免疫药理学（郑永唐）
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推荐引用方式
GB/T 7714 |
Lu, Y,Zhang, MX,Pang, W,et al. Transcription Factor ZNF683 Inhibits SIV/HIV Replication through Regulating IFN gamma Secretion of CD8+T Cells[J]. VIRUSES-BASEL,2022,14(4):-0.
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| APA |
Lu, Y.,Zhang, MX.,Pang, W.,Song, TZ.,Zheng, HY.,...&Zheng, YT.(2022).Transcription Factor ZNF683 Inhibits SIV/HIV Replication through Regulating IFN gamma Secretion of CD8+T Cells.VIRUSES-BASEL,14(4),-0.
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| MLA |
Lu, Y,et al."Transcription Factor ZNF683 Inhibits SIV/HIV Replication through Regulating IFN gamma Secretion of CD8+T Cells".VIRUSES-BASEL 14.4(2022):-0.
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