pH-sensitive chitosan nanoparticles loaded with dolutegravir as milk and food admixture for paediatric anti-HIV therapy

	pH-sensitive chitosan nanoparticles loaded with dolutegravir as milk and food admixture for paediatric anti-HIV therapy
	Dharshini, KP; Fang, H; Devi, DR; Yang, JX; Luo, RH; Zheng, YT; Brzezinski, M; Hari, BNV
	2021
发表期刊	CARBOHYDRATE POLYMERS
ISSN	0144-8617
卷号	256
摘要	The present study aims to develop Chitosan-based polymeric nanoparticles of anti-HIV drug Dolutegravir, to aid appropriate dose adjustment and ease of oral administration as milk and food admixture for children. The isolated Chitosan from the crab shell species Portunus Sanguinolentus has been characterized for their physicochemical properties. Nanoparticles were developed with varying ratio of drug: Chitosan and assessed for particle size (140-548 nm), zeta potential (+26.1 mV) with a maximum of 75 % drug content. Nanoparticles exhibited improved stability and drug release in the 0.1 N HCl medium compared to pure drug. The MTT assay and the Syncytia inhibition assay in C8166 (T-lymphatic cell line) infected with HIVIIIB viral strain, which showed better therapeutic efficiency and lesser cytotoxicity compared to the pure drug. In consonance with the data obtained, the use of chitosan from a novel source for drug delivery carrier has opened exceptional prospects for delivering drugs efficiently to paediatrics
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/13813
专题	科研部门_分子免疫药理学（郑永唐）
推荐引用方式 GB/T 7714	Dharshini, KP,Fang, H,Devi, DR,et al. pH-sensitive chitosan nanoparticles loaded with dolutegravir as milk and food admixture for paediatric anti-HIV therapy[J]. CARBOHYDRATE POLYMERS,2021,256.
APA	Dharshini, KP.,Fang, H.,Devi, DR.,Yang, JX.,Luo, RH.,...&Hari, BNV.(2021).pH-sensitive chitosan nanoparticles loaded with dolutegravir as milk and food admixture for paediatric anti-HIV therapy.CARBOHYDRATE POLYMERS,256.
MLA	Dharshini, KP,et al."pH-sensitive chitosan nanoparticles loaded with dolutegravir as milk and food admixture for paediatric anti-HIV therapy".CARBOHYDRATE POLYMERS 256(2021).

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