Dalbavancin binds ACE2 to block its interaction with SARS-CoV-2 spike protein and is effective in inhibiting SARS-CoV-2 infection in animal models

	Dalbavancin binds ACE2 to block its interaction with SARS-CoV-2 spike protein and is effective in inhibiting SARS-CoV-2 infection in animal models
	Wang, G; Yang, ML; Duan, ZL; Liu, FL; Jin, L; Long, CB; Zhang, M; Tang, XP; Xu, L; Li, YC; Kamau, PM; Yang, L; Liu, HQ; Xu, JW; Chen, JK; Zheng, YT; Peng, XZ; Lai, R
	2021
发表期刊	CELL RESEARCH
ISSN	1001-0602
卷号	31 期号:1 页码:17-24
摘要	Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a pandemic worldwide. Currently, however, no effective drug or vaccine is available to treat or prevent the resulting coronavirus disease 2019 (COVID-19). Here, we report our discovery of a promising anti-COVID-19 drug candidate, the lipoglycopeptide antibiotic dalbavancin, based on virtual screening of the FDA-approved peptide drug library combined with in vitro and in vivo functional antiviral assays. Our results showed that dalbavancin directly binds to human angiotensin-converting enzyme 2 (ACE2) with high affinity, thereby blocking its interaction with the SARS-CoV-2 spike protein. Furthermore, dalbavancin effectively prevents SARS-CoV-2 replication in Vero E6 cells with an EC50 of similar to 12 nM. In both mouse and rhesus macaque models, viral replication and histopathological injuries caused by SARS-CoV-2 infection are significantly inhibited by dalbavancin administration. Given its high safety and long plasma half-life (8-10 days) shown in previous clinical trials, our data indicate that dalbavancin is a promising anti-COVID-19 drug candidate.
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/13819
专题	科研部门_分子免疫药理学（郑永唐）
推荐引用方式 GB/T 7714	Wang, G,Yang, ML,Duan, ZL,et al. Dalbavancin binds ACE2 to block its interaction with SARS-CoV-2 spike protein and is effective in inhibiting SARS-CoV-2 infection in animal models[J]. CELL RESEARCH,2021,31(1):17-24.
APA	Wang, G.,Yang, ML.,Duan, ZL.,Liu, FL.,Jin, L.,...&Lai, R.(2021).Dalbavancin binds ACE2 to block its interaction with SARS-CoV-2 spike protein and is effective in inhibiting SARS-CoV-2 infection in animal models.CELL RESEARCH,31(1),17-24.
MLA	Wang, G,et al."Dalbavancin binds ACE2 to block its interaction with SARS-CoV-2 spike protein and is effective in inhibiting SARS-CoV-2 infection in animal models".CELL RESEARCH 31.1(2021):17-24.

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