| Bluetongue virus non-structural protein 3 (NS3) and NS4 coordinatively antagonize type I interferon signaling by targeting STAT1 |
| Li, ZR; Lu, DF; Yang, H; Li, ZY; Zhu, P; Xie, JR; Liao, DF; Zheng, YT; Li, HC
|
| 2021
|
| 发表期刊 | VETERINARY MICROBIOLOGY
 |
| ISSN | 0378-1135
|
| 卷号 | 254 |
| 摘要 | Previous studies have pointed out that bluetongue virus (BTV) down-regulates the expression levels of type I interferon (IFN-I) and inhibits IFN-I signaling by targeting on the Janus tyrosine kinase (JAK)-signal transducer and activator of transcription protein (STAT) pathway. However, individual viral protein could not effectively block IFN-I signaling. There is a need to explore the underlying mechanisms by which viral proteins of BTV coordinate to antagonize the IFN-I signaling. We investigated the coordinative role of BTV-1 nonstructural protein 3 (NS3) and NS4 in counteracting IFN-I signaling in the JAK-STAT pathway by directly interacting with STAT1. The NS3 and NS4 targeted the SH2 domain of STAT1 to inhibit its phosphorylation, heterodimerization, nuclear translocation, as well as activation of downstream genes of the JAK-STAT pathway. NS3 and NS4 impaired STAT1 phosphorylation induced by IFN-I in a dose dependent manner. Overall, this study confirmed that NS3 and NS4 of BTV participate in interfering with IFN-I signaling process. Also, a new mechanism employed by BTV to evade host innate immune responses was revealed. |
| 收录类别 | sci
|
| 语种 | 英语
|
| 文献类型 | 期刊论文
|
| 条目标识符 | http://ir.kiz.ac.cn/handle/152453/13825
|
| 专题 | 科研部门_分子免疫药理学（郑永唐）
|
推荐引用方式
GB/T 7714 |
Li, ZR,Lu, DF,Yang, H,et al. Bluetongue virus non-structural protein 3 (NS3) and NS4 coordinatively antagonize type I interferon signaling by targeting STAT1[J]. VETERINARY MICROBIOLOGY,2021,254.
|
| APA |
Li, ZR.,Lu, DF.,Yang, H.,Li, ZY.,Zhu, P.,...&Li, HC.(2021).Bluetongue virus non-structural protein 3 (NS3) and NS4 coordinatively antagonize type I interferon signaling by targeting STAT1.VETERINARY MICROBIOLOGY,254.
|
| MLA |
Li, ZR,et al."Bluetongue virus non-structural protein 3 (NS3) and NS4 coordinatively antagonize type I interferon signaling by targeting STAT1".VETERINARY MICROBIOLOGY 254(2021).
|
修改评论