| Consistency of spatial dynamics of HIV-1 and HCV among HIV-1/HCV coinfected drug users in China |
| Wang, Y; Chen, X; Ye, M; Pang, W; Zhang, CY; Xiong, SD; Zheng, YT
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| 2021
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| 发表期刊 | BMC INFECTIOUS DISEASES
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| 卷号 | 21期号:1 |
| 摘要 | Background As the transmission routes of human immunodeficiency virus type 1 (HIV-1) and hepatitis C virus (HCV) are similar, previous studies based on separate research on HIV-1 and HCV assumed a similar transmission pattern. However, few studies have focused on the possible correlation of the spatial dynamics of HIV-1 and HCV among HIV-1/HCV coinfected patients. Methods A total of 310 HIV-1/HCV coinfected drug users were recruited in Yingjiang and Kaiyuan prefectures, Yunnan Province, China. HIV-1 env, p17, pol and HCV C/E2, NS5B fragments were amplified and sequenced from serum samples. The genetic characteristics and spatial dynamics of HIV-1 and HCV were explored by phylogenetic, bootscanning, and phylogeographic analyses. Results Among HIV-1/HCV coinfected drug users, eight HCV subtypes (1a, 1b, 3a, 3b, 6a, 6n, 6v, and 6u) and two HIV-1 subtypes (subtype B and subtype C), three HIV-1 circulating recombinant forms (CRF01_AE, CRF07_BC and CRF08_BC), and four unique recombinant forms (URF_BC, URF_01B, URF_01C and URF_01BC) were identified. HCV subtype 3b was the most predominant subtype in both Yingjiang and Kaiyuan prefectures. The dominant circulating HIV-1 subtypes for drug users among the two areas were CRF08_BC and URF_BC. Maximum clade credibility trees revealed that both HIV-1 and HCV were transmitted from Yingjiang to Kaiyuan. Conclusions The spatial dynamics of HIV-1 and HCV among HIV-1/HCV coinfected drug users seem to have high consistency, providing theoretical evidence for the prevention of HIV-1 and HCV simultaneously. |
| 收录类别 | sci
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| 语种 | 英语
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| 文献类型 | 期刊论文
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| 条目标识符 | http://ir.kiz.ac.cn/handle/152453/13826
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| 专题 | 科研部门_分子免疫药理学（郑永唐）
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推荐引用方式
GB/T 7714 |
Wang, Y,Chen, X,Ye, M,et al. Consistency of spatial dynamics of HIV-1 and HCV among HIV-1/HCV coinfected drug users in China[J]. BMC INFECTIOUS DISEASES,2021,21(1).
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| APA |
Wang, Y.,Chen, X.,Ye, M.,Pang, W.,Zhang, CY.,...&Zheng, YT.(2021).Consistency of spatial dynamics of HIV-1 and HCV among HIV-1/HCV coinfected drug users in China.BMC INFECTIOUS DISEASES,21(1).
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| MLA |
Wang, Y,et al."Consistency of spatial dynamics of HIV-1 and HCV among HIV-1/HCV coinfected drug users in China".BMC INFECTIOUS DISEASES 21.1(2021).
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