Aging induces severe SIV infection accompanied by an increase in follicular CD8+T cells with overactive STAT3 signaling

	Aging induces severe SIV infection accompanied by an increase in follicular CD8+T cells with overactive STAT3 signaling
	Zheng, HY; Wang, XH; He, XY; Chen, M; Zhang, MX; Lian, XD; Song, JH; Hu, Y; Pang, W; Wang, Y; Hu, ZF; Lv, LB; Zheng, YT
	2022
发表期刊	CELLULAR & MOLECULAR IMMUNOLOGY
ISSN	1672-7681
卷号	19 期号:9 页码:1042-1053
摘要	The number of elderly people living with HIV is increasing globally, and the condition of this population is relatively complicated due to the dual effects of aging and HIV infection. However, the impact of HIV infection combined with aging on the immune homeostasis of secondary lymphoid organs remains unclear. Here, we used the simian immunodeficiency virus mac239 (SIVmac239) strain to infect six young and six old Chinese rhesus macaques (ChRMs) and compared the infection characteristics of the two groups in the chronic stage through multiplex immunofluorescence staining of lymph nodes. The results showed that the SIV production and CD4/CD8 ratio inversion in old ChRMs were more severe than those in young ChRMs in both the peripheral blood and the lymph nodes, especially when a large number of CD8+ T cells infiltrated the follicles and germinal centers. STAT3 in these follicular CXCR5+CD8+ T cells was highly activated, with high expression of granzyme B, which might be caused by the severe inflammatory milieu in the follicles of old ChRMs. This study indicates that aging may be a cofactor involved in SIV-induced immune disorders in secondary lymphoid tissues, affecting the effective antiviral activity of highly enriched follicular CXCR5+CD8+ cells.
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/13831
专题	科研部门_分子免疫药理学（郑永唐）
推荐引用方式 GB/T 7714	Zheng, HY,Wang, XH,He, XY,et al. Aging induces severe SIV infection accompanied by an increase in follicular CD8+T cells with overactive STAT3 signaling[J]. CELLULAR & MOLECULAR IMMUNOLOGY,2022,19(9):1042-1053.
APA	Zheng, HY.,Wang, XH.,He, XY.,Chen, M.,Zhang, MX.,...&Zheng, YT.(2022).Aging induces severe SIV infection accompanied by an increase in follicular CD8+T cells with overactive STAT3 signaling.CELLULAR & MOLECULAR IMMUNOLOGY,19(9),1042-1053.
MLA	Zheng, HY,et al."Aging induces severe SIV infection accompanied by an increase in follicular CD8+T cells with overactive STAT3 signaling".CELLULAR & MOLECULAR IMMUNOLOGY 19.9(2022):1042-1053.

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