| A tandem-repeat dimeric RBD protein-based covid-19 vaccine zf2001 protects mice and nonhuman primates |
| An, YL; Li, SH; Jin, XY; Han, JB; Xu, K; Xu, SY; Han, YX; Liu, CY; Zheng, TY; Liu, M; Yang, M; Song, TZ; Huang, BY; Zhao, L; Wang, W; A, RH; Cheng, YJ; Wu, CW; Huang, EQ; Yang, SL; Wong, G; Bi, YH; Ke, CW; Tan, WJ; Yan, JH; Zheng, YT; Dai, LP; Gao, GF
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| 2022
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| 发表期刊 | EMERGING MICROBES & INFECTIONS
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| 卷号 | 11期号:1页码:1058-1071 |
| 摘要 | Safe, efficacious, and deployable vaccines are urgently needed to control COVID-19 in the large-scale vaccination campaigns. We report here the preclinical studies of an approved protein subunit vaccine against COVID-19, ZF2001, which contains tandem-repeat dimeric receptor-binding domain (RBD) protein with alum-based adjuvant. We assessed vaccine immunogenicity and efficacy in both mice and non-human primates (NHPs). ZF2001 induced high levels of RBD-binding and SARS-CoV-2 neutralizing antibody in both mice and non-human primates, and elicited balanced T(H)1/T(H)2 cellular responses in NHPs. Two doses of ZF2001 protected Ad-hACE2-transduced mice against SARS-CoV-2 infection, as detected by reduced viral RNA and relieved lung injuries. In NHPs, vaccination of either 25 mu g or 50 mu g ZF2001 prevented infection with SARS-CoV-2 in lung, trachea, and bronchi, with milder lung lesions. No evidence of disease enhancement was observed in both animal models. ZF2001 has been approved for emergency use in China, Uzbekistan, Indonesia, and Columbia. The high safety, immunogenicity, and protection efficacy in both mice and NHPs found in this preclinical study was consistent with the results in human clinical trials. |
| 收录类别 | sci
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| 语种 | 英语
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| 文献类型 | 期刊论文
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| 条目标识符 | http://ir.kiz.ac.cn/handle/152453/13837
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| 专题 | 科研部门_分子免疫药理学（郑永唐）
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推荐引用方式
GB/T 7714 |
An, YL,Li, SH,Jin, XY,et al. A tandem-repeat dimeric RBD protein-based covid-19 vaccine zf2001 protects mice and nonhuman primates[J]. EMERGING MICROBES & INFECTIONS,2022,11(1):1058-1071.
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| APA |
An, YL.,Li, SH.,Jin, XY.,Han, JB.,Xu, K.,...&Gao, GF.(2022).A tandem-repeat dimeric RBD protein-based covid-19 vaccine zf2001 protects mice and nonhuman primates.EMERGING MICROBES & INFECTIONS,11(1),1058-1071.
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| MLA |
An, YL,et al."A tandem-repeat dimeric RBD protein-based covid-19 vaccine zf2001 protects mice and nonhuman primates".EMERGING MICROBES & INFECTIONS 11.1(2022):1058-1071.
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