| Dimeric Pyranonaphthoquinone Glycosides with Anti-HIV and Cytotoxic Activities from a Soil-Derived Streptomyces |
| He, X; Wang, YJ; Luo, RH; Yang, LM; Wang, L; Guo, DL; Yang, J; Deng, Y; Zheng, YT; Huang, SX
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| 2019
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| 发表期刊 | JOURNAL OF NATURAL PRODUCTS
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| ISSN | 0163-3864
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| 卷号 | 82期号:7页码:1813-1819 |
| 摘要 | Eight new sulfur-bridged pyranonaphthoquinone (PNQ) dimers, naquihexcins C-J (1-8), a new PNQ monomer, naquihexcin K (10), and three known analogues (9, 11, and 12) were isolated from Streptomyces sp. KIB3133. The new structures were elucidated by interpretation of spectroscopic data. Dimer 4 was synthesized via a cascade S(N)2 reactions between two monomers and sodium sulfide, an approach motivated by the proposed biosynthetic pathway of dimeric pyranonaphthoquinones. Naquihexcin E (3) exhibited moderate HIV-1 inhibitory activity. Naquihexcins C (1), E (3), and I (7) showed inhibitory effects against two tumor cell lines (HL-60 and MCF-7) with IC50 values ranging from 1.4 to 16.1 mu M. |
| 收录类别 | sci
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| 语种 | 英语
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| 文献类型 | 期刊论文
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| 条目标识符 | http://ir.kiz.ac.cn/handle/152453/13850
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| 专题 | 科研部门_分子免疫药理学（郑永唐）
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推荐引用方式
GB/T 7714 |
He, X,Wang, YJ,Luo, RH,et al. Dimeric Pyranonaphthoquinone Glycosides with Anti-HIV and Cytotoxic Activities from a Soil-Derived Streptomyces[J]. JOURNAL OF NATURAL PRODUCTS,2019,82(7):1813-1819.
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| APA |
He, X.,Wang, YJ.,Luo, RH.,Yang, LM.,Wang, L.,...&Huang, SX.(2019).Dimeric Pyranonaphthoquinone Glycosides with Anti-HIV and Cytotoxic Activities from a Soil-Derived Streptomyces.JOURNAL OF NATURAL PRODUCTS,82(7),1813-1819.
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| MLA |
He, X,et al."Dimeric Pyranonaphthoquinone Glycosides with Anti-HIV and Cytotoxic Activities from a Soil-Derived Streptomyces".JOURNAL OF NATURAL PRODUCTS 82.7(2019):1813-1819.
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