Two immunogenic recombinant protein vaccine candidates showed disparate protective efficacy against Zika virus infection in rhesus macaques

	Two immunogenic recombinant protein vaccine candidates showed disparate protective efficacy against Zika virus infection in rhesus macaques
	Yang, RH; Liu, QW; Pang, W; Gao, F; Liang, HB; Zhang, W; Lin, YL; Li, M; Liu, ZH; Gao, GF; Zhang, LQ; Xiao, H; Zheng, YT; Huang, Z; Jin, X
	2021
发表期刊	VACCINE
ISSN	0264-410X
卷号	39 期号:6 页码:915-925
摘要	Zika virus (ZIKV) infection has caused major public health problems recently. To develop subunit vaccines for ZIKV, we have previously constructed recombinant ZIKV envelope protein domain III (EDIII), and the entire ectodomain (E80, which comprises EDI, EDIT and EDIII), as vaccine candidates and showed both of them being immunogenic and protective in murine models. In this follow-up study, we compared these vaccine candidates in non-human primates. Both of them elicited neutralizing antibody responses, but only E80 immunization inhibited ZIKV infection in both peripheral blood and monkey tissues, whereas EDIII increased blood ZIKV RNA through possibly antibody-dependent enhancement. Further investigations revealed that the virion-binding antibody response in E80 immunized monkeys persisted longer and stronger than in EDIII immunized monkeys. These results demonstrate that E80 is superior to EDIII as a vaccine candidate, and that the magnitude, quality and durability of virion-binding neutralizing antibodies are correlates of protection. (C) 2021 Elsevier Ltd. All rights reserved.
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/13854
专题	科研部门_分子免疫药理学（郑永唐）
推荐引用方式 GB/T 7714	Yang, RH,Liu, QW,Pang, W,et al. Two immunogenic recombinant protein vaccine candidates showed disparate protective efficacy against Zika virus infection in rhesus macaques[J]. VACCINE,2021,39(6):915-925.
APA	Yang, RH.,Liu, QW.,Pang, W.,Gao, F.,Liang, HB.,...&Jin, X.(2021).Two immunogenic recombinant protein vaccine candidates showed disparate protective efficacy against Zika virus infection in rhesus macaques.VACCINE,39(6),915-925.
MLA	Yang, RH,et al."Two immunogenic recombinant protein vaccine candidates showed disparate protective efficacy against Zika virus infection in rhesus macaques".VACCINE 39.6(2021):915-925.

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