| A pathogen-like antigen-based vaccine confers immune protection against SARS-CoV-2 in non-human primates |
| Guo, C; Peng, YN; Lin, L; Pan, XY; Fang, MQ; Zhao, Y; Bao, KY; Li, RH; Han, JB; Chen, JR; Song, TZ; Feng, XL; Zhou, YH; Zhao, G; Zhang, LK ; Zheng, YT; Zhu, P; Hang, HY; Zhang, LQ; Hua, ZL; Deng, HY; Hou, BD
|
| 2021
|
| 发表期刊 | CELL REPORTS MEDICINE
 |
| ISSN | 2666-3791
|
| 卷号 | 2期号:11 |
| 摘要 | Activation of nucleic acid sensing Toll-like receptors (TLRs) in B cells is involved in antiviral responses by promoting B cell activation and germinal center responses. In order to take advantage of this natural pathway for vaccine development, synthetic pathogen-like antigens (PLAs) constructed of multivalent antigens with encapsulated TLR ligands can be used to activate B cell antigen receptors and TLRs in a synergistic manner. Here we report a PLA-based coronavirus disease 2019 (COVID-19) vaccine candidate designed by combining a phage-derived virus-like particle carrying bacterial RNA as TLR ligands with the receptor-binding domain of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) S protein as the target antigen. This PLA-based vaccine candidate induces robust neutralizing antibodies in both mice and non-human primates (NHPs). Using a NHP infection model, we demonstrate that the viral clearance is accelerated in vaccinated animals. In addition, the PLA-based vaccine induces a T helper 1 (Th1)-oriented response and a durable memory, supporting its potential for further clinical development. |
| 收录类别 | sci
|
| 语种 | 英语
|
| 文献类型 | 期刊论文
|
| 条目标识符 | http://ir.kiz.ac.cn/handle/152453/13855
|
| 专题 | 科研部门_分子免疫药理学（郑永唐）
|
推荐引用方式
GB/T 7714 |
Guo, C,Peng, YN,Lin, L,et al. A pathogen-like antigen-based vaccine confers immune protection against SARS-CoV-2 in non-human primates[J]. CELL REPORTS MEDICINE,2021,2(11).
|
| APA |
Guo, C.,Peng, YN.,Lin, L.,Pan, XY.,Fang, MQ.,...&Hou, BD.(2021).A pathogen-like antigen-based vaccine confers immune protection against SARS-CoV-2 in non-human primates.CELL REPORTS MEDICINE,2(11).
|
| MLA |
Guo, C,et al."A pathogen-like antigen-based vaccine confers immune protection against SARS-CoV-2 in non-human primates".CELL REPORTS MEDICINE 2.11(2021).
|
修改评论