Microplastics interact with SARS-CoV-2 and facilitate host cell infection

	Microplastics interact with SARS-CoV-2 and facilitate host cell infection
	Zhang, GF; Cao, GL; Luo, RH; Song, QL; Zeng, YQ; Liu, K; Qu, J; Lin, X; Liu, FL; Wang, GC; Li, HC; Li, L; Zheng, YT; Boraschi, D; Wu, LD; Chang, YZ; Li, Y
	2022
发表期刊	ENVIRONMENTAL SCIENCE-NANO
ISSN	2051-8153
卷号	9 期号:8 页码:2653-2664
摘要	Microplastics (MP) pollution is a global issue that raises concerns about potential toxicity for environmental and human health. The notion that SARS-CoV-2 is more stable when adsorbed on plastic surfaces urged us to examine whether the virus can attach to MP, which may facilitate infection upon inhalation or ingestion. Here, we describe that MP can bind SARS-CoV-2 pseudovirus on their surface and enhance infection of human cells in vitro. This enhanced in vitro infectivity was confirmed with authentic SARS-CoV-2, in parallel with increased expression of inflammation-related caspase-3, IL-8 and TNF-alpha genes. These results suggest that the presence of MP in the environment or in our respiratory or gastrointestinal tracts has the potential to interact with SARS-CoV-2, and potentially increase viral infectivity and spreading.
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/13856
专题	科研部门_分子免疫药理学（郑永唐）
推荐引用方式 GB/T 7714	Zhang, GF,Cao, GL,Luo, RH,et al. Microplastics interact with SARS-CoV-2 and facilitate host cell infection[J]. ENVIRONMENTAL SCIENCE-NANO,2022,9(8):2653-2664.
APA	Zhang, GF.,Cao, GL.,Luo, RH.,Song, QL.,Zeng, YQ.,...&Li, Y.(2022).Microplastics interact with SARS-CoV-2 and facilitate host cell infection.ENVIRONMENTAL SCIENCE-NANO,9(8),2653-2664.
MLA	Zhang, GF,et al."Microplastics interact with SARS-CoV-2 and facilitate host cell infection".ENVIRONMENTAL SCIENCE-NANO 9.8(2022):2653-2664.

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2023041180.pdf（4784KB）	期刊论文	出版稿	开放获取	CC BY-NC-SA	请求全文