A nanomaterial targeting the spike protein captures SARS-CoV-2 variants and promotes viral elimination

	A nanomaterial targeting the spike protein captures SARS-CoV-2 variants and promotes viral elimination
	Zhang, GF; Cong, YL; Liu, FL; Sun, JF; Zhang, JT; Cao, GL; Zhou, LQ; Yang, WJ; Song, QL; Wang, FJ; Liu, K; Qu, J; Wang, J; He, M; Feng, S; Baimanov, D; Xu, W; Luo, RH; Long, XY; Liao, SM; Fan, YP; Li, YF; Li, B; Shao, XM; Wang, GC; Fang, LJ; Wang, HY; Yu, XF; Chang, YZ; Zhao, YL; Li, L; Yu, P; Zheng, YT; Boraschi, D; Li, HC; Chen, CY; Wang, LM; Li, Y
	2022
发表期刊	NATURE NANOTECHNOLOGY
ISSN	1748-3387
卷号	17 期号:9 页码:993-+
摘要	While vaccines have curbed the COVID-19 pandemic, effective therapeutic treatments are few, and might be challenged by SARS-CoV-2 variants. A biocompatible, antiviral two-dimensional nanomaterial is now reported that firmly adsorbs the virus by interaction with the spike protein, inducing the conformational changes that lead to inhibition of viral infection in vitro and in animal models. The global emergency caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic can only be solved with effective and widespread preventive and therapeutic strategies, and both are still insufficient. Here, we describe an ultrathin two-dimensional CuInP2S6 (CIPS) nanosheet as a new agent against SARS-CoV-2 infection. CIPS exhibits an extremely high and selective binding capacity (dissociation constant (K-D) < 1 pM) for the receptor binding domain of the spike protein of wild-type SARS-CoV-2 and its variants of concern, including Delta and Omicron, inhibiting virus entry and infection in angiotensin converting enzyme 2 (ACE2)-bearing cells, human airway epithelial organoids and human ACE2-transgenic mice. On association with CIPS, the virus is quickly phagocytosed and eliminated by macrophages, suggesting that CIPS could be successfully used to capture and facilitate virus elimination by the host. Thus, we propose CIPS as a promising nanodrug for future safe and effective anti-SARS-CoV-2 therapy, and as a decontamination agent and surface-coating material to reduce SARS-CoV-2 infectivity.
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/13857
专题	科研部门_分子免疫药理学（郑永唐）
推荐引用方式 GB/T 7714	Zhang, GF,Cong, YL,Liu, FL,et al. A nanomaterial targeting the spike protein captures SARS-CoV-2 variants and promotes viral elimination[J]. NATURE NANOTECHNOLOGY,2022,17(9):993-+.
APA	Zhang, GF.,Cong, YL.,Liu, FL.,Sun, JF.,Zhang, JT.,...&Li, Y.(2022).A nanomaterial targeting the spike protein captures SARS-CoV-2 variants and promotes viral elimination.NATURE NANOTECHNOLOGY,17(9),993-+.
MLA	Zhang, GF,et al."A nanomaterial targeting the spike protein captures SARS-CoV-2 variants and promotes viral elimination".NATURE NANOTECHNOLOGY 17.9(2022):993-+.

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