More genes underwent positive selection in chimpanzee evolution than in human evolution

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	More genes underwent positive selection in chimpanzee evolution than in human evolution
	Bakewell, Margaret A.; Shi, Peng; Zhang, Jianzhi
	2007
发表期刊	PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
ISSN	0027-8424
卷号	104 期号:18 页码:7489-7494
摘要	Observations of numerous dramatic and presumably adaptive phenotypic modifications during human evolution prompt the common belief that more genes have undergone positive Darwinian selection in the human lineage than in the chimpanzee lineage since their evolutionary divergence 6-7 million years ago. Here, we test this hypothesis by analyzing nearly 14,000 genes of humans and chimps. To ensure an accurate and unbiased comparison, we select a proper outgroup, avoid sequencing errors, and verify statistical methods. Our results show that the number of positively selected genes is substantially smaller in humans than in chimps, despite a generally higher nonsynonymous substitution rate in humans. These observations are explainable by the reduced efficacy of natural selection in humans because of their smaller long-term effective population size but refute the anthropocentric view that a grand enhancement in Darwinian selection underlies human origins. Although human and chimp positively selected genes have different molecular functions and participate in different biological processes, the differences do not ostensibly correspond to the widely assumed adaptations of these species, suggesting how little is currently known about which traits have been under positive selection. Our analysis of the identified positively selected genes lends support to the association between human Mendelian diseases and past adaptations but provides no evidence for either the chromosomal speciation hypothesis or the widespread brain-gene acceleration hypothesis of human origins.
收录类别	sci
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/13941
专题	个人在本单位外知识产出
推荐引用方式 GB/T 7714	Bakewell, Margaret A.,Shi, Peng,Zhang, Jianzhi. More genes underwent positive selection in chimpanzee evolution than in human evolution[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2007,104(18):7489-7494.
APA	Bakewell, Margaret A.,Shi, Peng,&Zhang, Jianzhi.(2007).More genes underwent positive selection in chimpanzee evolution than in human evolution.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,104(18),7489-7494.
MLA	Bakewell, Margaret A.,et al."More genes underwent positive selection in chimpanzee evolution than in human evolution".PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 104.18(2007):7489-7494.

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2023041802.pdf（383KB）	期刊论文	出版稿	开放获取	CC BY-NC-SA	请求全文