Genomic Evidence for the Nonpathogenic State in HIV-1-Infected Northern Pig-Tailed Macaques

	Genomic Evidence for the Nonpathogenic State in HIV-1-Infected Northern Pig-Tailed Macaques
	Pang, W; Shao, Y; Zhuang, XL; Lu, Y; He, WQ; Zheng, HY; Xin, R; Zhang, MX; Zhang, XL; Song, JH; Tian, RR; Shen, F; Li, YH; Zhao, ZJ; Wu, DD; Zheng, YT
	2023
发表期刊	MOLECULAR BIOLOGY AND EVOLUTION
ISSN	0737-4038
卷号	40 期号:5
摘要	HIV-1 is a highly host-specific retrovirus that infects humans but not most nonhuman primates. Thus, the lack of a suitable primate model that can be directly infected with HIV-1 hinders HIV-1/AIDS research. In the previous study, we have found that the northern pig-tailed macaques (NPMs) are susceptible to HIV-1 infection but show a nonpathogenic state. In this study, to understand this macaque-HIV-1 interaction, we assembled a de novo genome and longitudinal transcriptome for this species during the course of HIV-1 infection. Using comparative genomic analysis, a positively selected gene, Toll-like receptor 8, was identified with a weak ability to induce an inflammatory response in this macaque. In addition, an interferon-stimulated gene, interferon alpha inducible protein 27, was upregulated in acute HIV-1 infection and acquired an enhanced ability to inhibit HIV-1 replication compared with its human ortholog. These findings coincide with the observation of persistently downregulated immune activation and low viral replication and can partially explain the AIDS-free state in this macaque following HIV-1 infection. This study identified a number of unexplored host genes that may hamper HIV-1 replication and pathogenicity in NPMs and provided new insights into the host defense mechanisms in cross-species infection of HIV-1. This work will facilitate the adoption of NPM as a feasible animal model for HIV-1/AIDS research.
收录类别	SCI
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/13973
专题	科研部门_分子免疫药理学（郑永唐）
推荐引用方式 GB/T 7714	Pang, W,Shao, Y,Zhuang, XL,et al. Genomic Evidence for the Nonpathogenic State in HIV-1-Infected Northern Pig-Tailed Macaques[J]. MOLECULAR BIOLOGY AND EVOLUTION,2023,40(5).
APA	Pang, W.,Shao, Y.,Zhuang, XL.,Lu, Y.,He, WQ.,...&Zheng, YT.(2023).Genomic Evidence for the Nonpathogenic State in HIV-1-Infected Northern Pig-Tailed Macaques.MOLECULAR BIOLOGY AND EVOLUTION,40(5).
MLA	Pang, W,et al."Genomic Evidence for the Nonpathogenic State in HIV-1-Infected Northern Pig-Tailed Macaques".MOLECULAR BIOLOGY AND EVOLUTION 40.5(2023).

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