Nsun2 coupling with RoRγt shapes the fate of Th17 cells and promotes colitis

	Nsun2 coupling with RoRγt shapes the fate of Th17 cells and promotes colitis
	Yang, WL; Qiu, WN; Zhang, T; Xu, K; Gu, ZJ; Zhou, Y; Xu, HJ; Yang, ZZ; Shen, B; Zhao, YL; Zhou, Q; Yang, Y; Li, W; Yang, PY; Yang, YG
	2023
发表期刊	NATURE COMMUNICATIONS
卷号	14 期号:1
摘要	Th17 cells produce a range of characteristic Th17 type cytokines and express transcription factors governed by epigenetic regulation to engage the Th17 programme. Here the authors implicate the RNA 5- methylcytosine (m(5)C) methyltransferase Nsun2 in Th17 cells and the promotion of colitis in a murine model. T helper 17 (Th17) cells are a subset of CD4(+) T helper cells involved in the inflammatory response in autoimmunity. Th17 cells secrete Th17 specific cytokines, such as IL-17A and IL17-F, which are governed by the master transcription factor RoR gamma t. However, the epigenetic mechanism regulating Th17 cell function is still not fully understood. Here, we reveal that deletion of RNA 5-methylcytosine (m(5)C) methyltransferase Nsun2 in mouse CD4(+) T cells specifically inhibits Th17 cell differentiation and alleviates Th17 cell-induced colitis pathogenesis. Mechanistically, RoR gamma t can recruit Nsun2 to chromatin regions of their targets, including Il17a and Il17f, leading to the transcription-coupled m(5)C formation and consequently enhanced mRNA stability. Our study demonstrates a m(5)C mediated cell intrinsic function in Th17 cells and suggests Nsun2 as a potential therapeutic target for autoimmune disease.
收录类别	SCI
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/13978
专题	科研部门_分子免疫药理学（郑永唐）
推荐引用方式 GB/T 7714	Yang, WL,Qiu, WN,Zhang, T,et al. Nsun2 coupling with RoRγt shapes the fate of Th17 cells and promotes colitis[J]. NATURE COMMUNICATIONS,2023,14(1).
APA	Yang, WL.,Qiu, WN.,Zhang, T.,Xu, K.,Gu, ZJ.,...&Yang, YG.(2023).Nsun2 coupling with RoRγt shapes the fate of Th17 cells and promotes colitis.NATURE COMMUNICATIONS,14(1).
MLA	Yang, WL,et al."Nsun2 coupling with RoRγt shapes the fate of Th17 cells and promotes colitis".NATURE COMMUNICATIONS 14.1(2023).

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