| Amphibian pore-forming protein By-CAT drives extracellular nutrient scavenging under cell nutrient |
| Liu, LZ; Liu, L; Shi, ZH; Bian, XL; Si, ZR; Wang, QQ; Xiang, Y; Zhang, Y
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| 2023
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| 发表期刊 | ISCIENCE
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| 卷号 | 26期号:5 |
| 摘要 | Nutrient acquisition is essential for animal cells. (3 beta -CAT is a pore-forming protein (PFP) and trefoil factor complex assembled under tight regulation identified in toad Bombina maxima. Here, we reported that B. maxima cells secreted (3 beta -CAT under glucose, glutamine, and pyruvate deficiency to scavenge extracellular pro-teins for their nutrient supply and survival. AMPK signaling positively regulated the expression and secretion of (3 beta -CAT. The PFP complex selectively bound extracellular proteins and promoted proteins uptake through endolysosomal pathways. Elevated intracellular amino acids, enhanced ATP production, and eventually prolonged cell survival were observed in the presence of (3 beta -CAT and extracellular proteins. Liposome assays indicated that high concentration of ATP negatively regulated the opening of (3 beta -CAT channels. Collectively, these results uncovered that (3 beta -CAT is an essential element in cell nutrient scavenging under cell nutrient deficiency by driving vesicular uptake of extracellular proteins, providing a new paradigm for PFPs in cell nutrient acquisition and meta-bolic flexibility. |
| 收录类别 | SCI
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| 语种 | 英语
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| 文献类型 | 期刊论文
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| 条目标识符 | http://ir.kiz.ac.cn/handle/152453/13988
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| 专题 | 科研部门_生物毒素与人类疾病（张云）
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推荐引用方式
GB/T 7714 |
Liu, LZ,Liu, L,Shi, ZH,et al. Amphibian pore-forming protein By-CAT drives extracellular nutrient scavenging under cell nutrient[J]. ISCIENCE,2023,26(5).
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| APA |
Liu, LZ.,Liu, L.,Shi, ZH.,Bian, XL.,Si, ZR.,...&Zhang, Y.(2023).Amphibian pore-forming protein By-CAT drives extracellular nutrient scavenging under cell nutrient.ISCIENCE,26(5).
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| MLA |
Liu, LZ,et al."Amphibian pore-forming protein By-CAT drives extracellular nutrient scavenging under cell nutrient".ISCIENCE 26.5(2023).
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