Alleviation of thermal nociception depends on heat-sensitive neurons and a TRP channel in the brain

	Alleviation of thermal nociception depends on heat-sensitive neurons and a TRP channel in the brain
	Liu, JQ; Liu, WW; Thakur, D; Mack, J; Spina, A; Montell, C
	2023
发表期刊	CURRENT BIOLOGY
ISSN	0960-9822
卷号	33 期号:12 页码:2397+
摘要	Acute avoidance of dangerous temperatures is critical for animals to prevent or minimize injury. Therefore, surface receptors have evolved to endow neurons with the capacity to detect noxious heat so that animals can initiate escape behaviors. Animals including humans have evolved intrinsic pain-suppressing systems to attenuate nociception under some circumstances. Here, using Drosophila melanogaster, we uncovered a new mechanism through which thermal nociception is suppressed. We identified a single descending neuron in each brain hemisphere, which is the center for suppression of thermal nociception. These Epi neurons, for Epione-the goddess of soothing of pain-express a nociception-suppressing neuropeptide Allatostatin C (AstC), which is related to a mammalian anti-nociceptive peptide, somatostatin. Epi neurons are direct sensors for noxious heat, and when activated they release AstC, which diminishes nociception. We found that Epi neurons also express the heat-activated TRP channel, Painless (Pain), and thermal activation of Epi neurons and the subsequent suppression of thermal nociception depend on Pain. Thus, while TRP channels are well known to sense noxious temperatures to promote avoidance behavior, this work reveals the first role for a TRP channel for detecting noxious temperatures for the purpose of suppressing rather than enhancing nociception behavior in response to hot thermal stimuli.
收录类别	SCI
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/14013
专题	科研部门_遗传多样性基因组学研究组（张国捷）
推荐引用方式 GB/T 7714	Liu, JQ,Liu, WW,Thakur, D,et al. Alleviation of thermal nociception depends on heat-sensitive neurons and a TRP channel in the brain[J]. CURRENT BIOLOGY,2023,33(12):2397+.
APA	Liu, JQ,Liu, WW,Thakur, D,Mack, J,Spina, A,&Montell, C.(2023).Alleviation of thermal nociception depends on heat-sensitive neurons and a TRP channel in the brain.CURRENT BIOLOGY,33(12),2397+.
MLA	Liu, JQ,et al."Alleviation of thermal nociception depends on heat-sensitive neurons and a TRP channel in the brain".CURRENT BIOLOGY 33.12(2023):2397+.

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