Evolution of the germline mutation rate across vertebrates

	Evolution of the germline mutation rate across vertebrates
	Bergeron, LA; Besenbacher, S; Zheng, J; Li, PY; Bertelsen, MF; Quintard, B; Hoffman, JI; Li, ZP; Leger, JS; Shao, CW; Stiller, J; Gilbert, MTP; Schierup, MH; Zhang, GJ
	2023
发表期刊	NATURE
ISSN	0028-0836
卷号	615 期号:7951 页码:285+
摘要	The germline mutation rate determines the pace of genome evolution and is an evolving parameter itself1. However, little is known about what determines its evolution, as most studies of mutation rates have focused on single species with different methodologies2. Here we quantify germline mutation rates across vertebrates by sequencing and comparing the high-coverage genomes of 151 parent- offspring trios from 68 species of mammals, fishes, birds and reptiles. We show that the per-generation mutation rate varies among species by a factor of 40, with mutation rates being higher for males than for females in mammals and birds, but not in reptiles and fishes. The generation time, age at maturity and species-level fecundity are the key life-history traits affecting this variation among species. Furthermore, species with higher long-term effective population sizes tend to have lower mutation rates per generation, providing support for the drift barrier hypothesis3. The exceptionally high yearly mutation rates of domesticated animals, which have been continually selected on fecundity traits including shorter generation times, further support the importance of generation time in the evolution of mutation rates. Overall, our comparative analysis of pedigree-based mutation rates provides ecological insights on the mutation rate evolution in vertebrates.
收录类别	SCI
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/14017
专题	科研部门_遗传多样性基因组学研究组（张国捷）
推荐引用方式 GB/T 7714	Bergeron, LA,Besenbacher, S,Zheng, J,et al. Evolution of the germline mutation rate across vertebrates[J]. NATURE,2023,615(7951):285+.
APA	Bergeron, LA.,Besenbacher, S.,Zheng, J.,Li, PY.,Bertelsen, MF.,...&Zhang, GJ.(2023).Evolution of the germline mutation rate across vertebrates.NATURE,615(7951),285+.
MLA	Bergeron, LA,et al."Evolution of the germline mutation rate across vertebrates".NATURE 615.7951(2023):285+.

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