Lineage-specific accelerated sequences underlying primate evolution

	Lineage-specific accelerated sequences underlying primate evolution
	Bi, XP; Zhou, L; Zhang, JJ; Feng, SH; Hu, M; Cooper, DN; Lin, JW; Li, JL; Wu, DD; Zhang, GJ
	2023
发表期刊	SCIENCE ADVANCES
ISSN	2375-2548
卷号	9 期号:22
摘要	Understanding the mechanisms underlying phenotypic innovation is a key goal of comparative genomic studies. Here, we investigated the evolutionary landscape of lineage-specific accelerated regions (LinARs) across 49 primate species. Genomic comparison with dense taxa sampling of primate species significantly im-proved LinAR detection accuracy and revealed many novel human LinARs associated with brain development or disease. Our study also yielded detailed maps of LinARs in other primate lineages that may have influenced lineage-specific phenotypic innovation and adaptation. Functional experimentation identified gibbon LinARs, which could have participated in the developmental regulation of their unique limb structures, whereas some LinARs in the Colobinae were associated with metabolite detoxification which may have been adaptive in relation to their leaf-eating diet. Overall, our study broadens knowledge of the functional roles of LinARs in primate evolution.
收录类别	SCI
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/14023
专题	科研部门_遗传多样性基因组学研究组（张国捷）
推荐引用方式 GB/T 7714	Bi, XP,Zhou, L,Zhang, JJ,et al. Lineage-specific accelerated sequences underlying primate evolution[J]. SCIENCE ADVANCES,2023,9(22).
APA	Bi, XP.,Zhou, L.,Zhang, JJ.,Feng, SH.,Hu, M.,...&Zhang, GJ.(2023).Lineage-specific accelerated sequences underlying primate evolution.SCIENCE ADVANCES,9(22).
MLA	Bi, XP,et al."Lineage-specific accelerated sequences underlying primate evolution".SCIENCE ADVANCES 9.22(2023).

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