Long-term presence of autoantibodies in plasma of cured leprosy patients

	Long-term presence of autoantibodies in plasma of cured leprosy patients
	Yang, X; Dong, H; Kuang, YQ; Yu, XF; Long, H; Zhang, CY; Wang, D; Zhang, DF; Li, YY
	2023
发表期刊	SCIENTIFIC REPORTS
ISSN	2045-2322
卷号	13 期号:1
摘要	Autoantibodies have been detected in leprosy patients, indicating that infection with M. leprae may lead to autoimmune disorders. However, whether autoimmune response last until patients are cured is unknown. Knowing the autoimmune response in cured leprosy patients is essential to identify whether symptoms are caused by leprosy itself or by other immune-related diseases. This knowledge is essential for the ongoing health management in cured leprosy patients where autoimmune disorders still exist. In our study, we selected six autoantibodies, including anticardiolipin antibody of IgG (ACA), anti-nuclear antibody (ANA), extractable nuclear antigen antibody (ENA), anti-streptolysin O (ASO), anti-double stranded DNA antibody (dsDNA), and rheumatoid factor (RF), that had been reported in leprosy patients as typical autoantibodies. We tested the six typical autoantibodies combined with LACC1, which encodes a protein associated with autoimmune disease such as Crohn's disease and is also the susceptible gene conferring leprosy risk, in cured leprosy patients through ELISA to assess the cured patient's immune status. We observed high positive rates of autoantibodies in cured leprosy patients, and the average plasma levels of five (ACA, ANA, ENA, ASO, and RF) out of the six autoantibodies were significantly higher in cured leprosy patients than in controls. The positive detection of autoantibodies is independent of the recovery period. Moreover, the level of these autoantibodies showed a strong positive correlation with the level of LACC1 in both controls and cured patients. This study showed that there is long-term autoimmunological activation in leprosy patients, even after decades of recovery. Autoimmune responses may influence the development and prognosis of leprosy. Special care should be given to posttreatment or cured leprosy patients regarding long-term autoimmunological activation.
收录类别	SCI
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/14025
专题	科研部门_复杂疾病表观遗传机制与模型(张登峰）
推荐引用方式 GB/T 7714	Yang, X,Dong, H,Kuang, YQ,et al. Long-term presence of autoantibodies in plasma of cured leprosy patients[J]. SCIENTIFIC REPORTS,2023,13(1).
APA	Yang, X.,Dong, H.,Kuang, YQ.,Yu, XF.,Long, H.,...&Li, YY.(2023).Long-term presence of autoantibodies in plasma of cured leprosy patients.SCIENTIFIC REPORTS,13(1).
MLA	Yang, X,et al."Long-term presence of autoantibodies in plasma of cured leprosy patients".SCIENTIFIC REPORTS 13.1(2023).

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