| New Monoterpenoid Indole Alkaloids from Tabernaemontana crassa Inhibit β-Amyloid42 Production and Phospho-Tau (Thr217) |
| Li, S; Han, LL; Huang, KP; Ma, YH; Guo, LL; Guo, YR; Ran, XQ; Yao, YG ; Hao, XJ; Luo, RC; Zhang, Y
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| 2023
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| 发表期刊 | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
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| 卷号 | 24期号:2 |
| 摘要 | Eleven monoterpenoid indole alkaloids, including three new ones, tabercrassines A-C (1-3), were isolated from the seeds of Tabernaemontana crassa. Tabercrassine A (1) is an ibogan-ibogan-type bisindole alkaloid which is formed by the polymerization of two classic ibogan-type monomers through a C3 unit aliphatic chain. Their structures were established by extensive analysis of HRESIMS, NMR, and ECD spectra. Cellular assays showed that alkaloids 1-3 all reduce A beta 42 production and inhibit phospho-tau (Thr217), a new biomarker of Alzheimer's disease [AD] associated with BACE1-, NCSTN-, GSK3 beta-, and CDK5-mediated pathways, suggesting these alkaloids' potential against AD. |
| 收录类别 | SCI
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| 语种 | 英语
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| 文献类型 | 期刊论文
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| 条目标识符 | http://ir.kiz.ac.cn/handle/152453/14031
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| 专题 | 科研部门_疾病机理遗传学和进化医学学科组（姚永刚）
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推荐引用方式
GB/T 7714 |
Li, S,Han, LL,Huang, KP,et al. New Monoterpenoid Indole Alkaloids from Tabernaemontana crassa Inhibit β-Amyloid42 Production and Phospho-Tau (Thr217)[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2023,24(2).
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| APA |
Li, S.,Han, LL.,Huang, KP.,Ma, YH.,Guo, LL.,...&Zhang, Y.(2023).New Monoterpenoid Indole Alkaloids from Tabernaemontana crassa Inhibit β-Amyloid42 Production and Phospho-Tau (Thr217).INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,24(2).
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| MLA |
Li, S,et al."New Monoterpenoid Indole Alkaloids from Tabernaemontana crassa Inhibit β-Amyloid42 Production and Phospho-Tau (Thr217)".INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 24.2(2023).
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