Entangling of Peptide Nanofibers Reduces the Invasiveness of SARS-CoV-2

	Entangling of Peptide Nanofibers Reduces the Invasiveness of SARS-CoV-2
	Yang, PP; Ye, XW; Liu, MQ; Yang, JX; Feng, XL; Li, YJ; Zhang, K; Liang, HW; Yi, Y; Wang, L; Liu, YX; Yang, XL; Shi, ZL; Feng, LQ; Chen, L; Xue, YT; Pan-Hammarström, Q; Wang, H; Zhao, YL
	2023
发表期刊	ADVANCED HEALTHCARE MATERIALS
ISSN	2192-2640
卷号	12 期号:24
摘要	The viral spike (S) protein on the surface of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) binds to angiotensin-converting enzyme 2 (ACE2) receptors on the host cells, facilitating its entry and infection. Here, functionalized nanofibers targeting the S protein with peptide sequences of IRQFFKK, WVHFYHK and NSGGSVH, which are screened from a high-throughput one-bead one-compound screening strategy, are designed and prepared. The flexible nanofibers support multiple binding sites and efficiently entangle SARS-CoV-2, forming a nanofibrous network that blocks the interaction between the S protein of SARS-CoV-2 and the ACE2 on host cells, and efficiently reduce the invasiveness of SARS-CoV-2. In summary, nanofibers entangling represents a smart nanomedicine for the prevention of SARS-CoV-2.
收录类别	SCI
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/14036
专题	科研部门_疫源动物病毒（杨兴娄）
推荐引用方式 GB/T 7714	Yang, PP,Ye, XW,Liu, MQ,et al. Entangling of Peptide Nanofibers Reduces the Invasiveness of SARS-CoV-2[J]. ADVANCED HEALTHCARE MATERIALS,2023,12(24).
APA	Yang, PP.,Ye, XW.,Liu, MQ.,Yang, JX.,Feng, XL.,...&Zhao, YL.(2023).Entangling of Peptide Nanofibers Reduces the Invasiveness of SARS-CoV-2.ADVANCED HEALTHCARE MATERIALS,12(24).
MLA	Yang, PP,et al."Entangling of Peptide Nanofibers Reduces the Invasiveness of SARS-CoV-2".ADVANCED HEALTHCARE MATERIALS 12.24(2023).

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2024053106.pdf（2950KB）	期刊论文	出版稿	开放获取	CC BY-NC-SA	请求全文