| Distinct Neural Representations and Cognitive Behaviors Attributable to Naturally Developed Active Avoidance or Reactive Escape Strategies in the Male Rat |
| Jing, L; Ma, C; Xu, L ; Richter-Levin, G
|
| 2023
|
| 发表期刊 | INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
 |
| ISSN | 1461-1457
|
| 卷号 | 26期号:11页码:761-772 |
| 摘要 | Background The high individual variability in coping with stress is often attributed to genetic background differences, sustained environmental conditions, or a combination of both. However, the neural mechanisms underlying coping style variability are still poorly understood.Methods Here we examined the impact of a single extended emotional challenge on coping style variability and the associated involvement of the hippocampus, medial prefrontal cortex (mPFC), and periaqueductal gray (PAG). Male Sprague-Dawley rats (n = 170) were trained in an extended 2-way shuttle avoidance (eTWSA) task for 7 days, and daily avoidance rates were measured. Forced swim test, elevated plus maze, or Morris water maze was tested before or after eTWSA exposure. Excitotoxic lesion of the hippocampal dentate gyrus (DG) was performed by Ibotenic infusion. Transient pharmacological blocking of DG, mPFC, or PAG was performed by muscimol or CNQX+TTX infusion.Results Exposing rats to eTWSA was found to lead to naturally developing dichotomous, not continuous, coping styles, which we termed active avoidance (AA) or reactive escape (RE). Prior emotional responses did not predict the developing coping style. AA was associated with beneficial outcomes, including reduced behavioral despair and improved spatial learning. RE led to impaired spatial retrieval. AA was abolished by lesioning or pharmacological blocking of the DG. RE was prevented by blocking mPFC or PAG.Conclusion The results indicate that a single exposure to a significant emotional challenge can lead, in otherwise healthy individuals, to dichotomous development of an active or reactive coping style with distinctive neural correlates and subsequent behavioral significance. |
| 收录类别 | SCI
|
| 语种 | 英语
|
| 文献类型 | 期刊论文
|
| 条目标识符 | http://ir.kiz.ac.cn/handle/152453/14053
|
| 专题 | 科研部门_学习记忆的分子神经机制（徐林）
|
推荐引用方式
GB/T 7714 |
Jing, L,Ma, C,Xu, L,et al. Distinct Neural Representations and Cognitive Behaviors Attributable to Naturally Developed Active Avoidance or Reactive Escape Strategies in the Male Rat[J]. INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY,2023,26(11):761-772.
|
| APA |
Jing, L,Ma, C,Xu, L,&Richter-Levin, G.(2023).Distinct Neural Representations and Cognitive Behaviors Attributable to Naturally Developed Active Avoidance or Reactive Escape Strategies in the Male Rat.INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY,26(11),761-772.
|
| MLA |
Jing, L,et al."Distinct Neural Representations and Cognitive Behaviors Attributable to Naturally Developed Active Avoidance or Reactive Escape Strategies in the Male Rat".INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY 26.11(2023):761-772.
|
修改评论