Brain developmental and cortical connectivity changes in transgenic monkeys carrying the human-specific duplicated gene SRGAP2C

KIZ OpenIR > 科研部门 > 比较基因组学（宿兵）

	Brain developmental and cortical connectivity changes in transgenic monkeys carrying the human-specific duplicated gene SRGAP2C
	Meng, XY; Lin, Q; Zeng, XR; Jiang, J; Li, M; Luo, X; Chen, KM; Wu, HX; Hu, Y; Liu, CR; Su, B
	2023
发表期刊	NATIONAL SCIENCE REVIEW
ISSN	2095-5138
卷号	10 期号:11
摘要	Human-specific duplicated genes contributed to phenotypic innovations during the origin of our own species, such as an enlarged brain and highly developed cognitive abilities. While prior studies on transgenic mice carrying the human-specific SRGAP2C gene have shown enhanced brain connectivity, the relevance to humans remains unclear due to the significant evolutionary gap between humans and rodents. In this study, to investigate the phenotypic outcome and underlying genetic mechanism of SRGAP2C, we generated transgenic cynomolgus macaques (Macaca fascicularis) carrying the human-specific SRGAP2C gene. Longitudinal MRI imaging revealed delayed brain development with region-specific volume changes, accompanied by altered myelination levels in the temporal and occipital regions. On a cellular level, the transgenic monkeys exhibited increased deep-layer neurons during fetal neurogenesis and delayed synaptic maturation in adolescence. Moreover, transcriptome analysis detected neotenic expression in molecular pathways related to neuron ensheathment, synaptic connections, extracellular matrix and energy metabolism. Cognitively, the transgenic monkeys demonstrated improved motor planning and execution skills. Together, our findings provide new insights into the mechanisms by which the newly evolved gene shapes the unique development and circuitry of the human brain.
收录类别	SCI
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/14056
专题	科研部门_比较基因组学（宿兵）
推荐引用方式 GB/T 7714	Meng, XY,Lin, Q,Zeng, XR,et al. Brain developmental and cortical connectivity changes in transgenic monkeys carrying the human-specific duplicated gene SRGAP2C[J]. NATIONAL SCIENCE REVIEW,2023,10(11).
APA	Meng, XY.,Lin, Q.,Zeng, XR.,Jiang, J.,Li, M.,...&Su, B.(2023).Brain developmental and cortical connectivity changes in transgenic monkeys carrying the human-specific duplicated gene SRGAP2C.NATIONAL SCIENCE REVIEW,10(11).
MLA	Meng, XY,et al."Brain developmental and cortical connectivity changes in transgenic monkeys carrying the human-specific duplicated gene SRGAP2C".NATIONAL SCIENCE REVIEW 10.11(2023).

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