How genomic insights into the evolutionary history of clouded leopards inform their conservation

	How genomic insights into the evolutionary history of clouded leopards inform their conservation
	Yuan, JQ; Wang, GQ; Zhao, L; Kitchener, AC; Sun, T; Chen, W; Huang, C; Wang, C; Xu, X; Wang, JH; Lu, HM; Xu, LL; Jiangzuo, Q; Murphy, WJ; Wu, DD; Li, G
	2023
发表期刊	SCIENCE ADVANCES
ISSN	2375-2548
卷号	9 期号:40
摘要	Clouded leopards (Neofelis spp.), a morphologically and ecologically distinct lineage of big cats, are severely threatened by habitat loss and fragmentation, targeted hunting, and other human activities. The long-held poor understanding of their genetics and evolution has undermined the effectiveness of conservation actions. Here, we report a comprehensive investigation of the whole genomes, population genetics, and adaptive evolution of Neofelis. Our results indicate the genus Neofelis arose during the Pleistocene, coinciding with glacial-induced climate changes to the distributions of savannas and rainforests, and signatures of natural selection associated with genes functioning in tooth, pigmentation, and tail development, associated with clouded leopards' unique adaptations. Our study highlights high-altitude adaptation as the main factor driving nontaxonomic population differentiation in Neofelis nebulosa. Population declines and inbreeding have led to reduced genetic diversity and the accumulation of deleterious variation that likely affect reproduction of clouded leopards, highlighting the urgent need for effective conservation efforts.
收录类别	SCI
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/14067
专题	科研部门_进化与发育转录组学（吴东东）
推荐引用方式 GB/T 7714	Yuan, JQ,Wang, GQ,Zhao, L,et al. How genomic insights into the evolutionary history of clouded leopards inform their conservation[J]. SCIENCE ADVANCES,2023,9(40).
APA	Yuan, JQ.,Wang, GQ.,Zhao, L.,Kitchener, AC.,Sun, T.,...&Li, G.(2023).How genomic insights into the evolutionary history of clouded leopards inform their conservation.SCIENCE ADVANCES,9(40).
MLA	Yuan, JQ,et al."How genomic insights into the evolutionary history of clouded leopards inform their conservation".SCIENCE ADVANCES 9.40(2023).

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2024061447.pdf（1997KB）	期刊论文	出版稿	开放获取	CC BY-NC-SA	请求全文