Integrative Omics Reveals Rapidly Evolving Regulatory Sequences Driving Primate Brain Evolution

	Integrative Omics Reveals Rapidly Evolving Regulatory Sequences Driving Primate Brain Evolution
	Zhuang, XL; Zhang, JJ; Shao, Y; Ye, YX; Chen, CY; Zhou, L; Wang, ZB; Luo, X; Su, B; Yao, YG; Cooper, DN; Hu, BX; Wang, L; Qi, XG; Lin, JW; Zhang, GJ; Wang, W; Sheng, NY; Wu, DD
	2023
发表期刊	MOLECULAR BIOLOGY AND EVOLUTION
ISSN	0737-4038
卷号	40 期号:8
摘要	Although the continual expansion of the brain during primate evolution accounts for our enhanced cognitive capabilities, the drivers of brain evolution have scarcely been explored in these ancestral nodes. Here, we performed large-scale comparative genomic, transcriptomic, and epigenomic analyses to investigate the evolutionary alterations acquired by brain genes and provide comprehensive listings of innovatory genetic elements along the evolutionary path from ancestral primates to human. The regulatory sequences associated with brain-expressed genes experienced rapid change, particularly in the ancestor of the Simiiformes. Extensive comparisons of single-cell and bulk transcriptomic data between primate and nonprimate brains revealed that these regulatory sequences may drive the high expression of certain genes in primate brains. Employing in utero electroporation into mouse embryonic cortex, we show that the primate-specific brain-biased gene BMP7 was recruited, probably in the ancestor of the Simiiformes, to regulate neuronal proliferation in the primate ventricular zone. Our study provides a comprehensive listing of genes and regulatory changes along the brain evolution lineage of ancestral primates leading to human. These data should be invaluable for future functional studies that will deepen our understanding not only of the genetic basis of human brain evolution but also of inherited disease.
收录类别	SCI
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/14069
专题	科研部门_进化与发育转录组学（吴东东）
推荐引用方式 GB/T 7714	Zhuang, XL,Zhang, JJ,Shao, Y,et al. Integrative Omics Reveals Rapidly Evolving Regulatory Sequences Driving Primate Brain Evolution[J]. MOLECULAR BIOLOGY AND EVOLUTION,2023,40(8).
APA	Zhuang, XL.,Zhang, JJ.,Shao, Y.,Ye, YX.,Chen, CY.,...&Wu, DD.(2023).Integrative Omics Reveals Rapidly Evolving Regulatory Sequences Driving Primate Brain Evolution.MOLECULAR BIOLOGY AND EVOLUTION,40(8).
MLA	Zhuang, XL,et al."Integrative Omics Reveals Rapidly Evolving Regulatory Sequences Driving Primate Brain Evolution".MOLECULAR BIOLOGY AND EVOLUTION 40.8(2023).

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