Two High-Quality Cygnus Genome Assemblies Reveal Genomic Variations Associated with Plumage Color

	Two High-Quality Cygnus Genome Assemblies Reveal Genomic Variations Associated with Plumage Color
	Chong, YQ; Tu, XL; Lu, Y; Gao, ZD; He, XM; Hong, JY; Wu, J; Wu, DD; Xi, DM; Deng, WD
	2023
发表期刊	INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
ISSN	1661-6596
卷号	24 期号:23
摘要	As an exemplary model for examining molecular mechanisms responsible for extreme phenotypic variations, plumage color has garnered significant interest. The Cygnus genus features two species, Cygnus olor and Cygnus atratus, that exhibit striking disparities in plumage color. However, the molecular foundation for this differentiation has remained elusive. Herein, we present two high-quality genomes for C. olor and C. atratus, procured using the Illumina and Nanopore technologies. The assembled genome of C. olor was 1.12 Gb in size with a contig N50 of 26.82 Mb, while its counterpart was 1.13 Gb in size with a contig N50 of 21.91 Mb. A comparative analysis unveiled three genes (TYR, SLC45A2, and SLC7A11) with structural variants in the melanogenic pathway. Notably, we also identified a novel gene, PWWP domain containing 2A (PWWP2A), that is related to plumage color, for the first time. Using targeted gene modification analysis, we demonstrated the potential genetic effect of the PWWP2A variant on pigment gene expression and melanin production. Finally, our findings offer insight into the intricate pattern of pigmentation and the role of polygenes in birds. Furthermore, these two high-quality genome references provide a comprehensive resource and perspective for comparative functional and genetic studies of evolution within the Cygnus genus.
收录类别	SCI
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/14076
专题	科研部门_进化与发育转录组学（吴东东）
推荐引用方式 GB/T 7714	Chong, YQ,Tu, XL,Lu, Y,et al. Two High-Quality Cygnus Genome Assemblies Reveal Genomic Variations Associated with Plumage Color[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2023,24(23).
APA	Chong, YQ.,Tu, XL.,Lu, Y.,Gao, ZD.,He, XM.,...&Deng, WD.(2023).Two High-Quality Cygnus Genome Assemblies Reveal Genomic Variations Associated with Plumage Color.INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,24(23).
MLA	Chong, YQ,et al."Two High-Quality Cygnus Genome Assemblies Reveal Genomic Variations Associated with Plumage Color".INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 24.23(2023).

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