Abietane derived diterpenoids as Cav3.1 antagonists from Salvia digitaloides

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	Abietane derived diterpenoids as Cav3.1 antagonists from Salvia digitaloides
	Zhao, JJ; Du, SZ; Hu, K; Hu, YL; Xia, F; Ye, YS; Yang, J; Nian, Y; Xu, G
	2023
发表期刊	CHINESE CHEMICAL LETTERS
ISSN	1001-8417
卷号	34 期号:4
摘要	Nineteen diterpenoids, including saldigitin A ( 1 ) bearing an unprecedented 10-methylated 6/7/6 carbon ring system, two new icetexanes ( 2 , 3 ), and two new nor-abietanes ( 5 , 6 ) were characterized from the roots of Salvia digitaloides. Their structures were elucidated by the analysis of the spectroscopic data, X-ray crystallography, and TDDFT calculations of ECD spectra. The novel architecture of 1 should be biogenetically derived through the cleavage and re-cyclization of the B/C rings from the normal abi-etane skeleton. Biologically, 1 -5 exhibited noticeable inhibitions on Cav 3.1 low voltage-gated Ca2 + channel (LVGCC), with IC50 values in the range of 3.43-11.70 mu mol/L. They are the first example of diterpenoids with 6/7/6 carbon rings system as Cav 3.1 antagonists. (c) 2023 Published by Elsevier B.V. on behalf of Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences.
收录类别	SCI
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/14081
专题	其他
推荐引用方式 GB/T 7714	Zhao, JJ,Du, SZ,Hu, K,et al. Abietane derived diterpenoids as Cav3.1 antagonists from Salvia digitaloides[J]. CHINESE CHEMICAL LETTERS,2023,34(4).
APA	Zhao, JJ.,Du, SZ.,Hu, K.,Hu, YL.,Xia, F.,...&Xu, G.(2023).Abietane derived diterpenoids as Cav3.1 antagonists from Salvia digitaloides.CHINESE CHEMICAL LETTERS,34(4).
MLA	Zhao, JJ,et al."Abietane derived diterpenoids as Cav3.1 antagonists from Salvia digitaloides".CHINESE CHEMICAL LETTERS 34.4(2023).

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