Blood-brain barrier dysfunction and Alzheimer's disease: associations, pathogenic mechanisms, and therapeutic potential

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	Blood-brain barrier dysfunction and Alzheimer's disease: associations, pathogenic mechanisms, and therapeutic potential
	Chen, YT; He, YF; Han, JL; Wei, WY; Chen, F
	2023
发表期刊	FRONTIERS IN AGING NEUROSCIENCE
ISSN	1663-4365
卷号	15
摘要	Alzheimer's disease (AD) is a common neurodegenerative disorder characterized by the accumulation of amyloid-beta (A beta), hyperphosphorylation of tau, and neuroinflammation in the brain. The blood-brain barrier (BBB) limits solutes from circulating blood from entering the brain, which is essential for neuronal functioning. Focusing on BBB function is important for the early detection of AD and in-depth study of AD pathogenic mechanisms. However, the mechanism of BBB alteration in AD is still unclear, which hinders further research on therapeutics that target the BBB to delay the progression of AD. The exact timing of the vascular abnormalities in AD and the complex cause-and-effect relationships remain uncertain. Thus, it is necessary to summarize and emphasize this process. First, in this review, the current evidence for BBB dysfunction in AD is summarized. Then, the interrelationships and pathogenic mechanisms between BBB dysfunction and the risk factors for AD, such as A beta, tau, neuroinflammation, apolipoprotein E (ApoE) genotype and aging, were analyzed. Finally, we discuss the current status and future directions of therapeutic AD strategies targeting the BBB. We hope that these summaries or reviews will allow readers to better understand the relationship between the BBB and AD.
收录类别	SCI
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/14084
专题	其他
推荐引用方式 GB/T 7714	Chen, YT,He, YF,Han, JL,et al. Blood-brain barrier dysfunction and Alzheimer's disease: associations, pathogenic mechanisms, and therapeutic potential[J]. FRONTIERS IN AGING NEUROSCIENCE,2023,15.
APA	Chen, YT,He, YF,Han, JL,Wei, WY,&Chen, F.(2023).Blood-brain barrier dysfunction and Alzheimer's disease: associations, pathogenic mechanisms, and therapeutic potential.FRONTIERS IN AGING NEUROSCIENCE,15.
MLA	Chen, YT,et al."Blood-brain barrier dysfunction and Alzheimer's disease: associations, pathogenic mechanisms, and therapeutic potential".FRONTIERS IN AGING NEUROSCIENCE 15(2023).

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