Extracellular vesicles from iPSC-MSCs alleviate chemotherapy-induced mouse ovarian damage via the ILK-PI3K/AKT pathway

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	Extracellular vesicles from iPSC-MSCs alleviate chemotherapy-induced mouse ovarian damage via the ILK-PI3K/AKT pathway
	Cao, RC; Lv, Y; Lu, G; Liu, HB; Wang, WM; Tan, CL; Su, XW; Xiong, ZQ; Ma, JL; Chan, WY
	2023
发表期刊	ZOOLOGICAL RESEARCH
ISSN	2095-8137
卷号	44 期号:3 页码:620+
摘要	Chemotherapy can significantly reduce follicle counts in ovarian tissues and damage ovarian stroma, causing endocrine disorder, reproductive dysfunction, and primary ovarian insufficiency (POI). Recent studies have suggested that extracellular vesicles (EVs) secreted from mesenchymal stem cells (MSCs) exert therapeutic effects in various degenerative diseases. In this study, transplantation of EVs from human induced pluripotent stem cell-derived MSCs (iPSC-MSC-EVs) resulted in significant restoration of ovarian follicle numbers, improved granulosa cell proliferation, and inhibition of apoptosis in chemotherapy-damaged granulosa cells, cultured ovaries, and in vivo ovaries in mice. Mechanistically, treatment with iPSC-MSC-EVs resulted in up-regulation of the integrin-linked kinase (ILK)-PI3K/AKT pathway, which is suppressed during chemotherapy, most likely through the transfer of regulatory microRNAs (miRNAs) targeting ILK pathway genes. This work provides a framework for the development of advanced therapeutics to ameliorate ovarian damage and POI in female chemotherapy patients.
收录类别	SCI
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/14091
专题	其他
推荐引用方式 GB/T 7714	Cao, RC,Lv, Y,Lu, G,et al. Extracellular vesicles from iPSC-MSCs alleviate chemotherapy-induced mouse ovarian damage via the ILK-PI3K/AKT pathway[J]. ZOOLOGICAL RESEARCH,2023,44(3):620+.
APA	Cao, RC.,Lv, Y.,Lu, G.,Liu, HB.,Wang, WM.,...&Chan, WY.(2023).Extracellular vesicles from iPSC-MSCs alleviate chemotherapy-induced mouse ovarian damage via the ILK-PI3K/AKT pathway.ZOOLOGICAL RESEARCH,44(3),620+.
MLA	Cao, RC,et al."Extracellular vesicles from iPSC-MSCs alleviate chemotherapy-induced mouse ovarian damage via the ILK-PI3K/AKT pathway".ZOOLOGICAL RESEARCH 44.3(2023):620+.

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