Genome-wide identification and spatiotemporal expression profiling of zinc finger SWIM domain-containing protein family genes

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	Genome-wide identification and spatiotemporal expression profiling of zinc finger SWIM domain-containing protein family genes
	Ul Hassan, I; Rehman, HM; Liu, ZR; Zhou, LJ; Samma, MK; Wang, CD; Rong, ZX; Qi, XF; Cai, DQ; Zhao, H
	2023
发表期刊	ZOOLOGICAL RESEARCH
ISSN	2095-8137
卷号	44 期号:3 页码:663-674
摘要	The biological function of the novel zinc-finger SWIM domain-containing protein family (ZSWIM) during embryonic development remains elusive. Here, we conducted a genome-wide analysis to explore the evolutionary processes of the ZSWIM gene family members in mice, Xenopus tropicalis, zebrafish, and humans. We identified nine putative ZSWIM genes in the human and mouse genome, eight in the Xenopus genome, and five in the zebrafish genome. Based on multiple sequence alignment, three members, ZSWIM5, ZSWIM6, and ZSWIM8, demonstrated the highest homology across all four species. Using available RNA sequencing (RNA-seq) data, ZSWIM genes were found to be widely expressed across different tissues, with distinct tissue-specific properties. To identify the functions of the ZSWIM protein family during embryogenesis, we examined temporal and spatial expression patterns of zswim family genes in Xenopus embryos. Quantitative real-time polymerase chain reaction (qRT-PCR) revealed that each member had a distinct expression profile. Whole-mount in situ hybridization showed that both zswim1 and zswim3 were maternally expressed genes; zswim5 and zswim6 were expressed throughout embryogenesis and displayed dynamic expression in the brain, eyes, somite, and bronchial arch at the late tailbud stages; zswim7 was detected in the eye area; zswim8 showed a dynamic expression pattern during the tailbud stages, with expression detected in the brain, eyes, and somite; zswim9 was faintly expressed throughout embryonic development. This study provides a foundation for future research to delineate the functions of ZSWIM gene members.
收录类别	SCI
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/14094
专题	其他
推荐引用方式 GB/T 7714	Ul Hassan, I,Rehman, HM,Liu, ZR,et al. Genome-wide identification and spatiotemporal expression profiling of zinc finger SWIM domain-containing protein family genes[J]. ZOOLOGICAL RESEARCH,2023,44(3):663-674.
APA	Ul Hassan, I.,Rehman, HM.,Liu, ZR.,Zhou, LJ.,Samma, MK.,...&Zhao, H.(2023).Genome-wide identification and spatiotemporal expression profiling of zinc finger SWIM domain-containing protein family genes.ZOOLOGICAL RESEARCH,44(3),663-674.
MLA	Ul Hassan, I,et al."Genome-wide identification and spatiotemporal expression profiling of zinc finger SWIM domain-containing protein family genes".ZOOLOGICAL RESEARCH 44.3(2023):663-674.

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20240614105.pdf（9756KB）	期刊论文	出版稿	开放获取	CC BY-NC-SA	请求全文