Large animal models of cardiac ischemia-reperfusion injury Where are we now?

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	Large animal models of cardiac ischemia-reperfusion injury Where are we now?
	Rahman, A; Li, YH; Chan, TK; Zhao, H; Xiang, YZ; Chang, X; Zhou, H; Xu, DC; Ong, SB
	2023
发表期刊	ZOOLOGICAL RESEARCH
ISSN	2095-8137
卷号	44 期号:3 页码:591-603
摘要	Large animal models of cardiac ischemia-reperfusion are critical for evaluation of the efficacy of cardioprotective interventions prior to clinical translation. Nonetheless, current cardioprotective strategies/interventions formulated in preclinical cardiovascular research are often limited to small animal models, which are not transferable or reproducible in large animal models due to different factors such as: (i) complex and varied features of human ischemic cardiac disease (ICD), which are challenging to mimic in animal models, (ii) significant differences in surgical techniques applied, and (iii) differences in cardiovascular anatomy and physiology between small versus large animals. This article highlights the advantages and disadvantages of different large animal models of preclinical cardiac ischemic reperfusion injury (IRI), as well as the different methods used to induce and assess IRI, and the obstacles faced in using large animals for translational research in the settings of cardiac IR.
收录类别	SCI
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/14103
专题	其他
推荐引用方式 GB/T 7714	Rahman, A,Li, YH,Chan, TK,et al. Large animal models of cardiac ischemia-reperfusion injury Where are we now?[J]. ZOOLOGICAL RESEARCH,2023,44(3):591-603.
APA	Rahman, A.,Li, YH.,Chan, TK.,Zhao, H.,Xiang, YZ.,...&Ong, SB.(2023).Large animal models of cardiac ischemia-reperfusion injury Where are we now?.ZOOLOGICAL RESEARCH,44(3),591-603.
MLA	Rahman, A,et al."Large animal models of cardiac ischemia-reperfusion injury Where are we now?".ZOOLOGICAL RESEARCH 44.3(2023):591-603.

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20240614111.pdf（1250KB）	期刊论文	出版稿	开放获取	CC BY-NC-SA	请求全文