Microbiota-derived acetate enhances host antiviral response via NLRP3

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	Microbiota-derived acetate enhances host antiviral response via NLRP3
	Niu, JL; Cui, MM; Yang, X; Li, J; Yao, YH; Guo, QH; Lu, AL; Qi, XP; Zhou, DM; Zhang, CH; Zhao, LP; Meng, GX
	2023
发表期刊	NATURE COMMUNICATIONS
卷号	14 期号:1
摘要	The NLRP3 inflammasome plays a pivotal role in clearing viral respiratory infection, but the molecular mechanism is not fully known. Here authors show that acetate, produced by gut bacteria, may enhance NLRP3-mediated type I interferon production following influenza infection in mice. Pathogenic viral infections represent a major challenge to human health. Host immune responses to respiratory viruses are closely associated with microbiome and metabolism via the gut-lung axis. It has been known that host defense against influenza A virus (IAV) involves activation of the NLRP3 inflammasome, however, mechanisms behind the protective function of NLRP3 are not fully known. Here we show that an isolated bacterial strain, Bifidobacterium pseudolongum NjM1, enriched in the gut microbiota of Nlrp3(-/-) mice, protects wild-type but not Nlrp3 deficient mice against IAV infection. This effect depends on the enhanced production of type I interferon (IFN-I) mediated by NjM1-derived acetate. Application of exogenous acetate reproduces the protective effect of NjM1. Mechanistically, NLRP3 bridges GPR43 and MAVS, and promotes the oligomerization and signalling of MAVS; while acetate enhances MAVS aggregation upon GPR43 engagement, leading to elevated IFN-I production. Thus, our data support a model of NLRP3 mediating enhanced induction of IFN-I via acetate-producing bacterium and suggest that the acetate-GPR43-NLRP3-MAVS-IFN-I signalling axis is a potential therapeutic target against respiratory viral infections.
收录类别	SCI
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/14109
专题	其他
推荐引用方式 GB/T 7714	Niu, JL,Cui, MM,Yang, X,et al. Microbiota-derived acetate enhances host antiviral response via NLRP3[J]. NATURE COMMUNICATIONS,2023,14(1).
APA	Niu, JL.,Cui, MM.,Yang, X.,Li, J.,Yao, YH.,...&Meng, GX.(2023).Microbiota-derived acetate enhances host antiviral response via NLRP3.NATURE COMMUNICATIONS,14(1).
MLA	Niu, JL,et al."Microbiota-derived acetate enhances host antiviral response via NLRP3".NATURE COMMUNICATIONS 14.1(2023).

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