Proteome-wide Mendelian randomization reveals the causal effects of immune-related plasma proteins on psychiatric disorders

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	Proteome-wide Mendelian randomization reveals the causal effects of immune-related plasma proteins on psychiatric disorders
	Dang, XL; Song, M; Lv, LX; Yang, YF; Luo, XJ
	2023
发表期刊	HUMAN GENETICS
ISSN	0340-6717
卷号	142 期号:6 页码:809-818
摘要	Immune dysregulation has been consistently reported in psychiatric disorders, however, the causes and mechanisms underlying immune dysregulation in psychiatric disorders remain largely unclear. Here we conduct a Mendelian randomization study by integrating plasma proteome and GWASs of schizophrenia, bipolar disorder and depression. The primate-specific immune-related protein BTN3A3 showed the most significant associations with all three psychiatric disorders. In addition, other immune-related proteins, including AIF1, FOXO3, IRF3, CFHR4, IGLON5, FKBP2, and PI3, also showed significant associations with psychiatric disorders. Our study showed that a proportion of psychiatric risk variants may contribute to disease risk by regulating immune-related plasma proteins, providing direct evidence that connect the genetic risk of psychiatric disorders to immune system.
收录类别	SCI
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/14119
专题	其他
推荐引用方式 GB/T 7714	Dang, XL,Song, M,Lv, LX,et al. Proteome-wide Mendelian randomization reveals the causal effects of immune-related plasma proteins on psychiatric disorders[J]. HUMAN GENETICS,2023,142(6):809-818.
APA	Dang, XL,Song, M,Lv, LX,Yang, YF,&Luo, XJ.(2023).Proteome-wide Mendelian randomization reveals the causal effects of immune-related plasma proteins on psychiatric disorders.HUMAN GENETICS,142(6),809-818.
MLA	Dang, XL,et al."Proteome-wide Mendelian randomization reveals the causal effects of immune-related plasma proteins on psychiatric disorders".HUMAN GENETICS 142.6(2023):809-818.

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2024061103.pdf（1000KB）	期刊论文	出版稿	开放获取	CC BY-NC-SA	请求全文