The genetic basis of onset age in schizophrenia: evidence and models

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	The genetic basis of onset age in schizophrenia: evidence and models
	Zhan, N; Sham, PC; So, HC; Lui, SSY
	2023
发表期刊	FRONTIERS IN GENETICS
卷号	14
摘要	Schizophrenia is a heritable neurocognitive disorder affecting about 1% of the population, and usually has an onset age at around 21-25 in males and 25-30 in females. Recent advances in genetics have helped to identify many common and rare variants for the liability to schizophrenia. Earlier evidence appeared to suggest that younger onset age is associated with higher genetic liability to schizophrenia. Clinical longitudinal research also found that early and very-early onset schizophrenia are associated with poor clinical, neurocognitive, and functional profiles. A recent study reported a heritability of 0.33 for schizophrenia onset age, but the genetic basis of this trait in schizophrenia remains elusive. In the pre-Genome-Wide Association Study (GWAS) era, genetic loci found to be associated with onset age were seldom replicated. In the post-Genome-Wide Association Study era, new conceptual frameworks are needed to clarify the role of onset age in genetic research in schizophrenia, and to identify its genetic basis. In this review, we first discussed the potential of onset age as a characterizing/subtyping feature for psychosis, and as an important phenotypic dimension of schizophrenia. Second, we reviewed the methods, samples, findings and limitations of previous genetic research on onset age in schizophrenia. Third, we discussed a potential conceptual framework for studying the genetic basis of onset age, as well as the concepts of susceptibility, modifier, and mixed genes. Fourth, we discussed the limitations of this review. Lastly, we discussed the potential clinical implications for genetic research of onset age of schizophrenia, and how future research can unveil the potential mechanisms for this trait.
收录类别	SCI
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/14124
专题	其他
推荐引用方式 GB/T 7714	Zhan, N,Sham, PC,So, HC,et al. The genetic basis of onset age in schizophrenia: evidence and models[J]. FRONTIERS IN GENETICS,2023,14.
APA	Zhan, N,Sham, PC,So, HC,&Lui, SSY.(2023).The genetic basis of onset age in schizophrenia: evidence and models.FRONTIERS IN GENETICS,14.
MLA	Zhan, N,et al."The genetic basis of onset age in schizophrenia: evidence and models".FRONTIERS IN GENETICS 14(2023).

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