Adaptive Evolution of the Spike Protein in Coronaviruses

	Adaptive Evolution of the Spike Protein in Coronaviruses
	Tang, XL; Qian, ZH; Lu, XM; Lu, J
	2023
发表期刊	MOLECULAR BIOLOGY AND EVOLUTION
ISSN	0737-4038
卷号	40 期号:4
摘要	Coronaviruses are single-stranded, positive-sense RNA viruses that can infect many mammal and avian species. The Spike (S) protein of coronaviruses binds to a receptor on the host cell surface to promote viral entry. The interactions between the S proteins of coronaviruses and receptors of host cells are extraordinarily complex, with coronaviruses from different genera being able to recognize the same receptor and coronaviruses from the same genus able to bind distinct receptors. As the coronavirus disease 2019 pandemic has developed, many changes in the S protein have been under positive selection by altering the receptor-binding affinity, reducing antibody neutralization activities, or affecting T-cell responses. It is intriguing to determine whether the selection pressure on the S gene differs between severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and other coronaviruses due to the host shift from nonhuman animals to humans. Here, we show that the S gene, particularly the S1 region, has experienced positive selection in both SARS-CoV-2 and other coronaviruses. Although the S1 N-terminal domain exhibits signals of positive selection in the pairwise comparisons in all four coronavirus genera, positive selection is primarily detected in the S1 C-terminal domain (the receptor-binding domain) in the ongoing evolution of SARS-CoV-2, possibly owing to the change in host settings and the widespread natural infection and SARS-CoV-2 vaccination in humans.
收录类别	SCI
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/14132
专题	科研部门_适应性进化与进化医学（吕雪梅）
推荐引用方式 GB/T 7714	Tang, XL,Qian, ZH,Lu, XM,et al. Adaptive Evolution of the Spike Protein in Coronaviruses[J]. MOLECULAR BIOLOGY AND EVOLUTION,2023,40(4).
APA	Tang, XL,Qian, ZH,Lu, XM,&Lu, J.(2023).Adaptive Evolution of the Spike Protein in Coronaviruses.MOLECULAR BIOLOGY AND EVOLUTION,40(4).
MLA	Tang, XL,et al."Adaptive Evolution of the Spike Protein in Coronaviruses".MOLECULAR BIOLOGY AND EVOLUTION 40.4(2023).

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