Modification of maternally defined H3K4me3 regulates the inviability of interspecific Xenopus hybrids

	Modification of maternally defined H3K4me3 regulates the inviability of interspecific Xenopus hybrids
	Long, Q; Yan, K; Wang, CD; Wen, YL; Qi, FR; Wang, H; Shi, P; Liu, XG; Chan, WY; Lu, XM; Zhao, H
	2023
发表期刊	SCIENCE ADVANCES
ISSN	2375-2548
卷号	9 期号:14
摘要	Increasing evidence suggests that interspecific hybridization is crucial to speciation. However, chromatin incom-patibility during interspecific hybridization often renders this process. Genomic imbalances such as chromo-somal DNA loss and rearrangements leading to infertility have been commonly noted in hybrids. The mechanism underlying reproductive isolation of interspecific hybridization remains elusive. Here, we identified that modification of maternally defined H3K4me3 in Xenopus laevis and Xenopus tropicalis hybrids determines the different fates of the two types of hybrids as texls with developmental arrest and viable lexts. Transcrip-tomics highlighted that the P53 pathway was overactivated, and the Wnt signaling pathway was suppressed in texls hybrids. Moreover, the lack of maternal H3K4me3 in texls disturbed the balance of gene expression between the L and S subgenomes in this hybrid. Attenuation of p53 can postpone the arrested development of texls. Our study suggests an additional model of reproductive isolation based on modifications of maternally defined H3K4me3. Commons
收录类别	SCI
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/14133
专题	科研部门_适应性进化与进化医学（吕雪梅）
推荐引用方式 GB/T 7714	Long, Q,Yan, K,Wang, CD,et al. Modification of maternally defined H3K4me3 regulates the inviability of interspecific Xenopus hybrids[J]. SCIENCE ADVANCES,2023,9(14).
APA	Long, Q.,Yan, K.,Wang, CD.,Wen, YL.,Qi, FR.,...&Zhao, H.(2023).Modification of maternally defined H3K4me3 regulates the inviability of interspecific Xenopus hybrids.SCIENCE ADVANCES,9(14).
MLA	Long, Q,et al."Modification of maternally defined H3K4me3 regulates the inviability of interspecific Xenopus hybrids".SCIENCE ADVANCES 9.14(2023).

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