Functional Analyses of Three Targeted DNA Antimicrobial Peptides Derived from Goats

	Functional Analyses of Three Targeted DNA Antimicrobial Peptides Derived from Goats
	Wang, AL; Zhou, MY; Chen, Q; Jin, H; Xu, GC; Guo, RY; Wang, JM; Lai, R
	2023
发表期刊	BIOMOLECULES
卷号	13 期号:10
摘要	With the increase in drug-resistant bacteria, new antibacterial drugs have emerged as a prominent area of research and development. Antimicrobial peptides (AMPs), as innate immune agents, have garnered significant attention due to their potent, rapid, and broad-spectrum antibacterial activity. This study focused on investigating the functionality of three AMPs (CATH 1, CATH 2, and MAP34-B) derived from goat submandibular glands. Among these AMPs, CATH 2 and MAP34-B exhibited direct antibacterial activity against both Gram-negative and Gram-positive bacteria, primarily targeting the bacterial membrane. Additionally, these two AMPs were found to have the potential to induce reactive oxygen species (ROS) production in bacterial cells and interact with bacterial genome DNA, which may play a crucial role in their mechanisms of action. Furthermore, both CATH 1 and CATH 2 demonstrated significant antioxidant activity, and all three AMPs exhibited potential anti-inflammatory activity. Importantly, the cytotoxic activity of these AMPs against mammalian cells was found to be weak, and their hemolytic activity was extremely low. Overall, the characteristics of these three AMPs found in goat submandibular glands offer new insights for the study of host protection from an immunological perspective. They hold promise as potential candidates for the development of novel antibacterial agents, particularly in the context of combating drug-resistant bacteria.
收录类别	SCI
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/14148
专题	科研部门_天然药物功能蛋白质学科组（赖仞）
推荐引用方式 GB/T 7714	Wang, AL,Zhou, MY,Chen, Q,et al. Functional Analyses of Three Targeted DNA Antimicrobial Peptides Derived from Goats[J]. BIOMOLECULES,2023,13(10).
APA	Wang, AL.,Zhou, MY.,Chen, Q.,Jin, H.,Xu, GC.,...&Lai, R.(2023).Functional Analyses of Three Targeted DNA Antimicrobial Peptides Derived from Goats.BIOMOLECULES,13(10).
MLA	Wang, AL,et al."Functional Analyses of Three Targeted DNA Antimicrobial Peptides Derived from Goats".BIOMOLECULES 13.10(2023).

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