| Longevity-Associated Transcription Factor ATF7 Promotes Healthspan by Suppressing Cellular Senescence and Systematic Inflammation |
| Huang, YQ; Ge, MX; Li, YH; Li, JL; Yu, Q ; Xiao, FH; Ao, HS; Yang, LQ; Li, J; He, YH; Kong, QP
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| 2023
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| 发表期刊 | AGING AND DISEASE
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| ISSN | 2152-5250
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| 卷号 | 14期号:4页码:1374-1389 |
| 摘要 | Aging is characterized by persistent low-grade systematic inflammation, which is largely responsible for the occurrence of various age-associated diseases. We and others have previously reported that long-lived people (such as centenarians) can delay the onset of or even escape certain major age-related diseases. Here, by screening blood transcriptome and inflammatory profiles, we found that long-lived individuals had a relatively lower inflammation level (IL6, TNF alpha), accompanied by up-regulation of activating transcription factor 7 (ATF7). Interestingly, ATF7 expression was gradually reduced during cellular senescence. Loss of ATF7 induced cellular senescence, while overexpression delayed senescence progress and senescence-associated secretory phenotype (SASP) secretion. We showed that the anti-senescence effects of ATF7 were achieved by inhibiting nuclear factor kappa B (NF-kappa B) signaling and increasing histone H3K9 dimethylation (H3K9me2). In Caenorhabditis elegans, ATF7 overexpression significantly suppressed aging biomarkers and extended lifespan. Our findings suggest that ATF7 is a longevity-promoting factor that lowers cellular senescence and inflammation in long-lived individuals. |
| 收录类别 | SCI
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| 语种 | 英语
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| 文献类型 | 期刊论文
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| 条目标识符 | http://ir.kiz.ac.cn/handle/152453/14157
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| 专题 | 科研部门_分子人类学（孔庆鹏）
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推荐引用方式
GB/T 7714 |
Huang, YQ,Ge, MX,Li, YH,et al. Longevity-Associated Transcription Factor ATF7 Promotes Healthspan by Suppressing Cellular Senescence and Systematic Inflammation[J]. AGING AND DISEASE,2023,14(4):1374-1389.
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| APA |
Huang, YQ.,Ge, MX.,Li, YH.,Li, JL.,Yu, Q.,...&Kong, QP.(2023).Longevity-Associated Transcription Factor ATF7 Promotes Healthspan by Suppressing Cellular Senescence and Systematic Inflammation.AGING AND DISEASE,14(4),1374-1389.
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| MLA |
Huang, YQ,et al."Longevity-Associated Transcription Factor ATF7 Promotes Healthspan by Suppressing Cellular Senescence and Systematic Inflammation".AGING AND DISEASE 14.4(2023):1374-1389.
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