Metabolic Modeling Identifies a Novel Molecular Type of Glioblastoma Associated with Good Prognosis

KIZ OpenIR > 科研部门 > 分子人类学（孔庆鹏）

	Metabolic Modeling Identifies a Novel Molecular Type of Glioblastoma Associated with Good Prognosis
	Shen, Q; Yang, H; Kong, QP; Li, GH; Li, L
	2023
发表期刊	METABOLITES
卷号	13 期号:2
摘要	Glioblastoma (GBM) is one of the most aggressive forms of cancer. Although IDH1 mutation indicates a good prognosis and a potential target for treatment, most GBMs are IDH1 wild-type. Identifying additional molecular markers would help to generate personalized therapies and improve patient outcomes. Here, we used our recently developed metabolic modeling method (genome-wide precision metabolic modeling, GPMM) to investigate the metabolic profiles of GBM, aiming to identify additional novel molecular markers for this disease. We systematically analyzed the metabolic reaction profiles of 149 GBM samples lacking IDH1 mutation. Forty-eight reactions showing significant association with prognosis were identified. Further analysis indicated that the purine recycling, nucleotide interconversion, and folate metabolism pathways were the most robust modules related to prognosis. Considering the three pathways, we then identified the most significant GBM type for a better prognosis, namely N+P-. This type presented high nucleotide interconversion (N+) and low purine recycling (P-). N+P--type exhibited a significantly better outcome (log-rank p = 4.7 x 10(-7)) than that of N-P+. GBM patients with the N+P--type had a median survival time of 19.6 months and lived 65% longer than other GBM patients. Our results highlighted a novel molecular type of GBM, which showed relatively high frequency (26%) in GBM patients lacking the IDH1 mutation, and therefore exhibits potential in GBM prognostic assessment and personalized therapy.
收录类别	SCI
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/14158
专题	科研部门_分子人类学（孔庆鹏）
推荐引用方式 GB/T 7714	Shen, Q,Yang, H,Kong, QP,et al. Metabolic Modeling Identifies a Novel Molecular Type of Glioblastoma Associated with Good Prognosis[J]. METABOLITES,2023,13(2).
APA	Shen, Q,Yang, H,Kong, QP,Li, GH,&Li, L.(2023).Metabolic Modeling Identifies a Novel Molecular Type of Glioblastoma Associated with Good Prognosis.METABOLITES,13(2).
MLA	Shen, Q,et al."Metabolic Modeling Identifies a Novel Molecular Type of Glioblastoma Associated with Good Prognosis".METABOLITES 13.2(2023).

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2024061217.pdf（3079KB）	期刊论文	出版稿	开放获取	CC BY-NC-SA	请求全文