| Scrutiny of genome-wide somatic mutation profiles in centenarians identifies the key genomic regions for human longevity | |
| Wang, HT; Zhao, L; Yang, LQ; Ge, MX; Yang, XL; Gao, ZL; Cun, YP; Xiao, FH; Kong, QP | |
| 2023 | |
| 发表期刊 | AGING CELL
 |
| ISSN | 1474-9718 |
| 摘要 | Somatic mutations accumulate with age and are associated closely with human health, their characterization in longevity cohorts remains largely unknown. Here, by analyzing whole genome somatic mutation profiles in 73 centenarians and 51 younger controls in China, we found that centenarian genomes are characterized by a markedly skewed distribution of somatic mutations, with many genomic regions being specifically conserved but displaying a high function potential. This, together with the observed more efficient DNA repair ability in the long-lived individuals, supports the existence of key genomic regions for human survival during aging, with their integrity being of essential to human longevity. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kiz.ac.cn/handle/152453/14160 |
| 专题 | 科研部门_分子人类学（孔庆鹏） |
| 推荐引用方式 GB/T 7714 | Wang, HT,Zhao, L,Yang, LQ,et al. Scrutiny of genome-wide somatic mutation profiles in centenarians identifies the key genomic regions for human longevity[J]. AGING CELL,2023. |
| APA | Wang, HT.,Zhao, L.,Yang, LQ.,Ge, MX.,Yang, XL.,...&Kong, QP.(2023).Scrutiny of genome-wide somatic mutation profiles in centenarians identifies the key genomic regions for human longevity.AGING CELL. |
| MLA | Wang, HT,et al."Scrutiny of genome-wide somatic mutation profiles in centenarians identifies the key genomic regions for human longevity".AGING CELL (2023). |
| 条目包含的文件 | ||||||
| 文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
| 2024053111.pdf（491KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | 请求全文 | |
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