Targeting cuproptosis by zinc pyrithione in triple-negative breast cancer

	Targeting cuproptosis by zinc pyrithione in triple-negative breast cancer
	Yang, X; Deng, L; Diao, XH; Yang, SY; Zou, L; Yang, Q; Li, J; Nie, JY; Zhao, LA; Jiao, BW
	2023
发表期刊	ISCIENCE
卷号	26 期号:11
摘要	Triple-negative breast cancer (TNBC) poses a considerable challenge due to its aggressive nature. Notably, metal ion-induced cell death, such as ferroptosis, has garnered significant attention and demonstrated potential implications for cancer. Recently, cuproptosis, a potent cell death pathway reliant on copper, has been identified. However, whether cuproptosis can be targeted for cancer treatment remains uncertain. Here, we screened the US Food and Drug Administration (FDA)-approved drug library and identified zinc pyrithione (ZnPT) as a compound that significantly inhibited TNBC progression. RNA sequencing revealed that ZnPT disrupted copper homeostasis. Furthermore, ZnPT facilitated the oligomerization of dihydrolipoamide S-acetyltransferase, a landmark molecule of cuproptosis. Clinically, high expression levels of cuproptosis-related proteins were significantly correlated with poor prognosis in TNBC patients. Collectively, these findings indicate that ZnPT can induce cell death by targeting and disrupting copper homeostasis, providing a potential experimental foundation for exploring cuproptosis as a target in drug discovery for TNBC patients.
收录类别	SCI
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/14162
专题	科研部门_发育的印迹调控与进化学（焦保卫）
推荐引用方式 GB/T 7714	Yang, X,Deng, L,Diao, XH,et al. Targeting cuproptosis by zinc pyrithione in triple-negative breast cancer[J]. ISCIENCE,2023,26(11).
APA	Yang, X.,Deng, L.,Diao, XH.,Yang, SY.,Zou, L.,...&Jiao, BW.(2023).Targeting cuproptosis by zinc pyrithione in triple-negative breast cancer.ISCIENCE,26(11).
MLA	Yang, X,et al."Targeting cuproptosis by zinc pyrithione in triple-negative breast cancer".ISCIENCE 26.11(2023).

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