| Transient neurogenesis in ischemic cortex from Sox2+ astrocytes |
| Yang, JL; Fan, H; Fu, FF; Guo, BL; Huang, Y; Sun, L; Wang, WT; Xing, JL; Hu, XT; Ding, YQ; Zhang, K; Hu, YZ; Wang, YZ
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| 2023
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| 发表期刊 | NEURAL REGENERATION RESEARCH
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| ISSN | 1673-5374
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| 卷号 | 18期号:7页码:1521-1526 |
| 摘要 | The adult cortex has long been regarded as non-neurogenic. Whether injury can induce neurogenesis in the adult cortex is still controversial. Here, we report that focal ischemia stimulates a transient wave of local neurogenesis. Using 5' -bromo-2' -deoxyuridine labeling, we demonstrated a rapid generation of doublecortin-positive neuroblasts that died quickly in mouse cerebral cortex following ischemia. Nestin-Cre(ER)-based cell ablation and fate mapping showed a small contribution of neuroblasts by subventricular zone neural stem cells. Using a mini-photothrombotic ischemia mouse model and retrovirus expressing green fluorescent protein labeling, we observed maturation of locally generated new neurons. Furthermore, fate tracing analyses using PDGFR alpha-, GFAP-, and Sox2-Cre(ER) mice showed a transient wave of neuroblast generation in mild ischemic cortex and identified that Sox2-positive astrocytes were the major neurogenic cells in adult cortex. In addition, a similar upregulation of Sox2 and appearance of neuroblasts were observed in the focal ischemic cortex of Macaca mulatta. Our findings demonstrated a transient neurogenic response of Sox2-positive astrocytes in ischemic cortex, which suggests the possibility of inducing neuronal regeneration by amplifying this intrinsic response in the future. |
| 收录类别 | SCI
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| 语种 | 英语
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| 文献类型 | 期刊论文
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| 条目标识符 | http://ir.kiz.ac.cn/handle/152453/14176
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| 专题 | 科研部门_神经系统编码（胡新天）
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推荐引用方式
GB/T 7714 |
Yang, JL,Fan, H,Fu, FF,et al. Transient neurogenesis in ischemic cortex from Sox2+ astrocytes[J]. NEURAL REGENERATION RESEARCH,2023,18(7):1521-1526.
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| APA |
Yang, JL.,Fan, H.,Fu, FF.,Guo, BL.,Huang, Y.,...&Wang, YZ.(2023).Transient neurogenesis in ischemic cortex from Sox2+ astrocytes.NEURAL REGENERATION RESEARCH,18(7),1521-1526.
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| MLA |
Yang, JL,et al."Transient neurogenesis in ischemic cortex from Sox2+ astrocytes".NEURAL REGENERATION RESEARCH 18.7(2023):1521-1526.
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