Angiopoietin-1 promotes triple-negative breast cancer cell proliferation by upregulating carboxypeptidase A4

KIZ OpenIR > 科研部门 > 肿瘤生物学（陈策实）

	Angiopoietin-1 promotes triple-negative breast cancer cell proliferation by upregulating carboxypeptidase A4
	Liu, X; Liang, HC; Fang, H; Xiao, J; Yang, CY; Zhou, ZM; Feng, J; Chen, CS
	2023
发表期刊	ACTA BIOCHIMICA ET BIOPHYSICA SINICA
ISSN	1672-9145
卷号	55 期号:9 页码:1487-1495
摘要	Angiopoietin-1 (ANG1) is a pro-angiogenic regulator that contributes to the progression of solid tumors by stimulating the proliferation, migration and tube formation of vascular endothelial cells, as well as the renewal and stability of blood vessels. However, the functions and mechanisms of ANG1 in triple-negative breast cancer (TNBC) are unclear. The clinical sample database shows that a higher level of ANG1 in TNBC is associated with poor prognosis compared to non-TNBC. In addition, knockdown of ANG1 inhibits TNBC cell proliferation and induces cell cycle G1 phase arrest and apoptosis. Overexpression of ANG1 promotes tumor growth in nude mice. Mechanistically, ANG1 promotes TNBC by upregulating carboxypeptidase A4 (CPA4) expression. Overall, the ANG1-CPA4 axis can be a therapeutic target for TNBC.
收录类别	SCI
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/14180
专题	科研部门_肿瘤生物学（陈策实）
推荐引用方式 GB/T 7714	Liu, X,Liang, HC,Fang, H,et al. Angiopoietin-1 promotes triple-negative breast cancer cell proliferation by upregulating carboxypeptidase A4[J]. ACTA BIOCHIMICA ET BIOPHYSICA SINICA,2023,55(9):1487-1495.
APA	Liu, X.,Liang, HC.,Fang, H.,Xiao, J.,Yang, CY.,...&Chen, CS.(2023).Angiopoietin-1 promotes triple-negative breast cancer cell proliferation by upregulating carboxypeptidase A4.ACTA BIOCHIMICA ET BIOPHYSICA SINICA,55(9),1487-1495.
MLA	Liu, X,et al."Angiopoietin-1 promotes triple-negative breast cancer cell proliferation by upregulating carboxypeptidase A4".ACTA BIOCHIMICA ET BIOPHYSICA SINICA 55.9(2023):1487-1495.

条目包含的文件
文件名称/大小	文献类型	版本类型	开放类型	使用许可
2024053102.pdf（2444KB）	期刊论文	出版稿	开放获取	CC BY-NC-SA	请求全文